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Major depressive disorder tied to increased peripheral inflammation

09 Jan 2019

C-reactive protein (CRP) levels appear to be elevated in patients with major depressive disorder (MDD) and even more so in those who are resistant to treatment, a study has found.

The study included 102 treatment-resistant patients with MDD presently experiencing depression (mean age 36.5 years; 70.6 percent female), 48 treatment-responsive patients with MDD not presently experiencing depression (mean age 35.9 years; 66.7 percent female), 48 patients with untreated MDD (mean age 35.1 years; 64.6 percent female) and 54 healthy volunteers (mean age 34.2 years; 68.5 percent female).

Researchers evaluated high-sensitivity CRP in peripheral venous blood, body mass index (BMI), depression, anxiety and childhood trauma. They estimated group differences and used partial least squares (PLS) analysis to examine the relationships between CRP and specific clinical phenotypes.

BMI-corrected CRP was significantly higher in the treatment-resistant group (p= 0.007; Cohen's d, 0.47) but not significantly so in the treatment-responsive (d, 0.29) and untreated (d, 0.18) groups relative to the control group.

PLS showed an optimal two-factor solution that explained 34.7 percent of variation in clinical measures and 36.0 percent of variation in CRP. Clinical phenotypes such as vegetative depressive symptoms, BMI, state anxiety, and feeling unloved as a child or wishing for a different childhood were strongly associated with CRP. These phenotypes heavily weighted on the first PLS component.

The present data indicate that patients with MDD stratified for proinflammatory biomarkers, such as CRP, have a distinctive clinical profile potentially responsive to second-line treatment with anti-inflammatory drugs, researchers said.

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Most Read Articles
5 days ago
In patients with type 2 diabetes, obesity may be protective against vision-threatening diabetic retinopathy, a recent Korea study has shown.
Roshini Claire Anthony, 4 days ago

Men with metastatic hormone-sensitive prostate cancer (mHSPC) who receive testosterone suppression therapy may have a better survival outcome with the addition of enzalutamide over other non-steroidal anti-androgen (NSAA) therapies, according to the phase III ENZAMET* trial.

07 Jun 2019
Low-dose aspirin therapy does not confer significant benefits to elderly patients with hypertension, but treatment appears to increase the risk of haemorrhagic events, suggest a Japan study.
4 days ago
The use of opioids may have limited long-term efficacy in the management of chronic noncancer pain, reports a new study.