Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
5 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.

Major depression: Getting a little help from zinc

01 Oct 2020

In patients with major depressive disorder (MDD) being treated with antidepressants, zinc supplementation contributes to a substantial reduction in depressive symptoms, a study has found.

The researchers searched multiple online databases for trials that assessed whether zinc supplementation could prevent depression in healthy individuals or reduce depressive symptoms in those with MDD. The initial search yielded 12,322 articles. Six studies were included in the review, and five of these were pooled for the meta-analysis.

Two studies were conducted in Poland, one in Guatemala, one in Japan, and one in Iran. Only one study involved children. Duration of supplementation ranged from 10 to 12 weeks, with doses varying between 7 mg and 25 mg, administered daily or weekly.

Compared with placebo, zinc supplementation produced a significant reduction in the Beck Depression Inventory score (standardized mean difference [SMD], –0.36, 95 percent confidence interval [CI], –0.67 to –0.04).

Results were consistent in the subgroup of individuals aged 40 years (SMD, –0.61, 95 percent CI, –1.12 to –0.09).

One way that zinc may reduce depression symptoms is by inhibition of the ionotropic glutamate receptor N-methyl-D-aspartate (NMDA), the activation of which facilitates increased glutamatergic neurotransmission, which is in turn associated with depression and neurotoxicity, according to the researchers. [Pol J Pharmacol 2001;53:641-645; Prog Neuropsychopharmacol Biol Psychiatry 2011;35:693-701]

Zinc aids in the function of brain and neural structures by modulating synaptic transmission and acting as an endogenous neuromodulator of important receptors such as NMDA and a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic (AMPA), and c-aminobutyric acid (GABA), they added. [Brain Res Rev 2009;62:33-44]

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
5 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.