Most Read Articles
Roshini Claire Anthony, 3 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

Stephen Padilla, 4 days ago
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
Tristan Manalac, 25 May 2020
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.
Dr. Wong Soon Tee, 4 days ago
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.

Magnetic resonance unreliable for assessing NASH treatment response

06 Mar 2020

Magnetic resonance imaging may not be a reliable strategy for detecting changes in liver histology and may thus have limited value in assessing treatment response in patients with fatty liver, reports a new study.

The study included 121 patients with nonalcoholic steatohepatitis (NASH) who had paired measurements of intrahepatic triglyceride (IHTG) content, collected through magnetic resonance spectroscopy and liver histology.

Researchers found no significant correlation between changes in IHTG content and histological response to pioglitazone. For example, the resolution of NASH appeared to be comparable between those who showed a more-than 30-percent drop in IHTG content and those with a lower degree of reduction.

Similarly, a 2-point reduction in the nonalcoholic fatty liver disease activity score without worsening fibrosis occurred comparably in those who did vs did not show a 30-percent drop in IHTG. At no specific IHTG cutoff point was the prediction of NASH resolution significant.

Moreover, changes in IHTG, when plotted alongside the rate of improvement of different histological parameters, showed no significant predictive patterns.

Changes in lobular inflammation, liver fibrosis or hepatocyte ballooning also occurred independently of reductions in IHTG content.

“In the current work, we have shown that changes in IHTG content after treatment with pioglitazone or placebo do not predict histological or metabolic changes. The clinical implication of our findings is that MRI-based imaging may not be as reliable as previously believed to guide about the clinical efficacy of a given intervention in patients with NASH,” said researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Hepatology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 3 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

Stephen Padilla, 4 days ago
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
Tristan Manalac, 25 May 2020
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.
Dr. Wong Soon Tee, 4 days ago
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.