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Natalia Reoutova, 21 Nov 2019

Final analysis of the POEMS (Prevention of Early Menopause) study finds that breast cancer (BC) patients treated with the gonadotrophin-releasing hormone agonist (GnRHa) goserelin, in addition to chemotherapy, are more likely to avoid premature menopause and to become pregnant without negatively impacting disease-related outcomes.

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Macular sparing, optic nerve visibility predict low-risk histopathology in unilateral retinoblastoma

20 Sep 2019

Low-risk histopathologic features at primary enucleation are predicted by the presence of macular sparing, optic nerve visibility, <1 quadrant of retinal detachment (RD) or a combination thereof, which suggest safe trial eye salvage, according to a study. No clinical sign is associated with high-risk histopathologic features.

Thirty-eight eyes with vitreous seeding and normal intraocular pressure were included. The median diagnosis to enucleation interval was 4 days (range, 0–14 days). Histopathologic analysis diagnosed four (10.5 percent) high-risk and 34 (89.5 percent) low-risk eyes.

High-risk eyes were shown to have massive choroidal invasion (n=4) or trans-scleral, extraocular and postlaminar optic nerve invasion (n=1). Clinical findings were as follows: macular involvement (n=31), complete optic nerve obscuration (n=27) and RD (n=28).

Of the eyes with high-risk histopathologic features, 13 percent (4/31; 95 percent CI, 1–25 percent) had macular involvement, 15 percent (4/27; 1–28 percent) had complete optic nerve obscuration, and 14 percent (4/28; 1–27 percent) had RD.

Macular sparing (7/7; 47–100 percent), optic nerve visibility (10/10; 63–100 percent) and <1 quadrant of RD (10/10; 63–100 percent) predicted low-risk histopathologic features.

Furthermore, one child who lacked all three clinical low-risk predictive features with high-risk histopathologic features (pT3a) developed metastases and died. The other children were alive and well (mean follow-up, 65 months).

This retrospective, noncomparative, single-institutional, observational case series included children with unilateral cT2b/group D retinoblastoma managed with primary enucleation at the Hospital for Sick Children in Toronto, Canada, from January 2008 through February 2018.

The authors obtained and assessed the following data: clinical features (ie, intraocular pressure, optic nerve obscuration, macular involvement, tumour seeding and serous RD >1 quadrant), timing to enucleation, histopathologic features and follow-up.

“Attempted eye salvage for unilateral retinoblastoma may risk tumour spread compared with primary enucleation,” the investigators noted.

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Most Read Articles
Natalia Reoutova, 21 Nov 2019

Final analysis of the POEMS (Prevention of Early Menopause) study finds that breast cancer (BC) patients treated with the gonadotrophin-releasing hormone agonist (GnRHa) goserelin, in addition to chemotherapy, are more likely to avoid premature menopause and to become pregnant without negatively impacting disease-related outcomes.

Jairia Dela Cruz, 6 days ago
In breast cancer, especially hormone-negative tumours, an ultrasound-guided core biopsy (CNB) is useful for predicting pathologic complete response (pCR) to chemotherapy and may thus help to avoid surgery for some patients, a study has found.
Stephen Padilla, 5 days ago
Circulating miR-155 may be potentially used as a diagnostic and therapeutic monitoring marker in breast cancer, suggests an Indonesian study presented at the 2019 Asia Congress of the European Society for Medical Oncology (ESMO Asia 2019).
Christina Lau, 14 Feb 2019
Progress in the treatment of rare cancers has been named Advance of the Year by the American Society of Clinical Oncology (ASCO).