Most Read Articles
06 Dec 2018
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
Pearl Toh, Yesterday
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
6 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
4 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.

LV diastolic dysfunction predicts mortality in patients with systemic sclerosis

10 Oct 2018

Diastolic dysfunction commonly occurs in patients with systemic sclerosis (SSc), and its presence is linked to high mortality, according to a recent study. Additionally, diastolic dysfunction is a better predictor of death as compared to pulmonary hypertension (PH).

Diastolic function was examined in 275 and 186 SSc patients at baseline and at follow-up, respectively. Of the 275 patients, 46 (17 percent) were diagnosed with diastolic dysfunction and 195 (71 percent) had normal diastolic function at baseline.

There was an increase in the proportion of diastolic dysfunction from 17 percent to 29 percent after a median follow-up of 3.4 years (interquartile range, 1.6–6.2 years). During follow-up, more than half (57 percent) of the patients with diastolic dysfunction at baseline died, compared with 13 percent of those with normal diastolic function.

Right heart catheterization was performed in 86 patients at baseline. PH was diagnosed in 43 individuals, of whom 60 percent died. Multivariable Cox regression analyses revealed that diastolic dysfunction (hazard ratio [HR], 3.7; 95 percent CI, 1.69–8.14; c-index, 0.89) was better than PH (HR, 2.0; 1.1–3.9; c-index, 0.84) in terms of predicting mortality.

This study recruited SSc patients followed prospectively at the Oslo University Hospital from 2003 to 2016 with available echocardiography results as well as matched control participants. The authors used echocardiography to assess diastolic dysfunction according to the 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging guidelines. Right heart catheterization was used to diagnose PH. All patients had available vital status information.

“Primary cardiac affection is common and is a major cause of death in SSc, but there are knowledge gaps regarding the effect of cardiac dysfunction on mortality,” the authors noted.

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Most Read Articles
06 Dec 2018
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
Pearl Toh, Yesterday
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
6 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
4 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.