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Lung function slightly helps lung cancer prediction in nonsmokers

28 Sep 2019

Impaired lung function modestly improves lung cancer prediction in nonsmokers, a recent study has found. In turn, asthma, obesity, air pollution and low birthweight are all associated with worse lung function.

Accessing the UK Biobank cohort, researchers identified 222,274 never-smokers who were eligible for the analysis. Majority (n=222,106; mean age, 55.6±8.1 years; 38.5 percent) remained healthy, while 168 (mean age, 60.7±6.5 years; 29.8 percent male) developed lung cancer. Volumetric measures of lung function, including forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC), were used for the determination of lung function impairment.

Never-smokers accounted for 13 percent of all lung cancers in the study population, with an incidence rate of 13.4 per 100,000 person-years. Those who developed the malignancy tended to have worse lung function, as determined by FEV1 <80 percent (p=0.018), FEV1/FVC <70 percent (p=0.008), or both (p=0.008).

Multivariable Poisson regression analysis found that having a history of asthma is significantly associated with impaired lung function, as defined by both FEV1 and FEV1/FCV criteria (incidence rate ratio [IRR], 5.17, 95 percent CI, 4.97–5.38). The same was true for ambient air pollution (IRR, 1.80, 1.49–2.17) and having low birthweight (IRR, 1.21, 1.10–1.33).

Fine & Gray competing risk regression models, adjusted for lung function, found that age, sex, family history of lung cancer and previous malignancies were all significant determinants of subsequent lung cancer risk. FEV1/FVC, on the other hand, was not.

“[W]e found limited improvement in predictive performance when incorporating lung function into the risk prediction model for lung cancer among never-smokers,” said researchers.

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Most Read Articles
Elaine Soliven, 4 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

3 days ago
Among individuals with abdominal obesity, drinking beverages with artificial sweeteners (ASBs) or no sugar (USBs) instead of sugar-sweetened beverages (SSBs) helps lose body weight, a study has found. However, USBs have a more favourable effect on sweet taste preference compared with ASBs.
Stephen Padilla, 5 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 4 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.