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Lower urinary tract symptoms up frailty risk in elderly men

09 Sep 2020

Older community-dwelling men with moderate or severe lower urinary tract symptoms (LUTS) are more likely to have phenotypic frailty than those with milder LUTS, a recent study has found.

Researchers conducted a cross-sectional analysis of 5,979 elderly community-dwelling men (aged ≥65 years), in whom LUTS was assessed using the American Urologic Association Symptom Index. Frailty was assessed in terms of low lean mass, exhaustion, low physical activity, slowness, and weakness.

Most of the participants (n=3,230; 54 percent) had no or mild LUTS, and this group tended to be younger than their counterparts who had moderate (n=2,351; 39 percent) or severe (n=398; 7 percent) LUTS.

The crude prevalence rate of frailty increased according to LUTS severity: 7 percent in the none/mild group, 11 percent in the moderate group, and 18 percent in the severe group. Men who fulfilled at least three of the frailty phenotype components were deemed to be frail.

Similarly, the prevalence of intermediate-stage frailty, defined as having one or two of the phenotype components, shared a direct interaction with LUTS severity. The proportion of robust men, on the other hand, dropped with increasing LUTS severity.

Multivariable regression analysis confirmed that LUTS was a significant risk factor for frailty. Moderate LUTS, for instance, increased the odds of frailty by over 40 percent (odds ratio [OR], 1.41, 95 percent confidence interval [CI], 1.14–1.74). Severe LUTS, in comparison, statistically increased the likelihood of intermediate-stage frailty (OR, 1.35, 95 percent CI, 1.06–1.73) and frailty (OR, 2.51, 95 percent CI, 1.76–3.55).

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Most Read Articles
6 days ago
Regular practice of yoga postures confers benefits for glucose control, oxidative stress, inflammatory response, and sleep quality in patients with type 2 diabetes, a study has found.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
09 Jan 2021
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