Most Read Articles
Pearl Toh, 10 Jul 2018
A dual-hormone artificial pancreas (DAP) with a rapid delivery of insulin and pramlintide in a fixed ratio improves glycaemic control and reduces glucose variability in adults with type 1 diabetes (T1D) compared with first-generation artificial pancreas delivering insulin alone, according to a study presented at ADA 2018.
5 days ago
Chocolate consumption is not associated with risk of coronary heart disease (CHD), stroke or both combined in postmenopausal women free of pre-existing major chronic disease, a study suggests.
Pearl Toh, 5 days ago
More intensive lowering of LDL-C levels was associated with a progressively greater survival benefit than less intensive approach, when the baseline LDL-C levels were ≥100 mg/dL, reveals a meta-analysis of 34 randomized trials.
4 days ago
Switching from thiazide diuretic to ipragliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, leads to improvements in metabolic parameters and body mass composition without affecting blood pressure in type 2 diabetes (T2D) patients, a recent study has found.

Lower pathological stage seen in neoadjuvant chemo-treated patients with urothelial carcinoma

11 Jul 2018

Pathological stage distribution is lower in patients with high-risk upper tract urothelial carcinoma treated with neoadjuvant chemotherapy than in those treated with radical nephroureterectomy alone, reports a study.

The authors retrospectively analysed the records of 240 patients with upper tract urothelial carcinoma at The John Hopkins Hospital from 2003 to 2017 to evaluate differences in their pathological stage distribution.

Neoadjuvant chemotherapy was offered prior to radical nephroureterectomy to patients with biopsy-proven high-grade disease and a visible lesion on cross-sectional imaging (study group). A control group consisting of a time-matched cohort of patients with biopsy-proven high-grade disease underwent extirpative surgery alone. The authors assessed clinical and pathological variables between the cohorts via chi-square and Fisher exact tests.

Thirty-two patients in the study group and 208 in the control group were included in the analysis. The study group demonstrated significantly lower pathological stage compared with the control group (p<0.001).

There were significantly fewer patients with pT2 disease or higher treated with neoadjuvant chemotherapy (37.5 percent vs 59.6 percent; p=0.02). A 46.5-percent reduction was noted in the prevalence of pT3 disease or higher among patients without clinically node positive or low volume metastatic disease in the study group (25.9 percent vs 48.4 percent; p=0.04).

In addition, a 9.4-percent complete remission rate was observed in patients who underwent neoadjuvant chemotherapy.

“High-risk upper tract urothelial carcinoma has been associated with poor survival outcomes,” the authors said. “Limited retrospective data support neoadjuvant chemotherapy prior to radical nephroureterectomy.”

Editor's Recommendations
Most Read Articles
Pearl Toh, 10 Jul 2018
A dual-hormone artificial pancreas (DAP) with a rapid delivery of insulin and pramlintide in a fixed ratio improves glycaemic control and reduces glucose variability in adults with type 1 diabetes (T1D) compared with first-generation artificial pancreas delivering insulin alone, according to a study presented at ADA 2018.
5 days ago
Chocolate consumption is not associated with risk of coronary heart disease (CHD), stroke or both combined in postmenopausal women free of pre-existing major chronic disease, a study suggests.
Pearl Toh, 5 days ago
More intensive lowering of LDL-C levels was associated with a progressively greater survival benefit than less intensive approach, when the baseline LDL-C levels were ≥100 mg/dL, reveals a meta-analysis of 34 randomized trials.
4 days ago
Switching from thiazide diuretic to ipragliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, leads to improvements in metabolic parameters and body mass composition without affecting blood pressure in type 2 diabetes (T2D) patients, a recent study has found.