Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
12 Jan 2020
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.
Stephen Padilla, 5 days ago
The Lancet Commission on Hypertension Group has recently released a position statement that contains a list of recommendations for the improvement of accuracy standards for devices that measure blood pressure (BP).

Lower lung volumes, airflow obstruction predict endothelial dysfunction in women

3 days ago

Airflow obstruction and lower lung volumes appear to increase the risk of endothelial dysfunction in middle-aged women, suggests a recent study. On the other hand, the evidence for such association in men is weaker.

The association between lung and endothelial function was modified by sex. Lower values of pre- and postbronchodilator spirometry, total lung capacity, and functional residual capacity (FRC) correlated with worse endothelial function among women (p<0.05). Similar associations were seen after adjusting for smoking, asthma diagnoses, fitness and body mass index.

These associations were weaker among men, with endothelial function correlating only with FRC, airway conductance and postbronchodilator forced expiratory volume in 1 s/forced vital capacity ratios. Gas transfer did not correlate with endothelial function in either sex.

“These findings may partly explain the increased risk of cardiovascular disease among people with poor lung function but suggest that there are sex differences in this association,” the investigators said.

This study measured systemic endothelial function using peripheral arterial tonometry to calculate the Framingham reactive hyperaemia index, and evaluated lung function using spirometry, plethysmographic lung volumes, airway conductance and gas transfer.

Regression analyses were carried out to assess the associations between lung and endothelial function with and without adjustment for potential confounding factors.

“Chronic lung disease is associated with impaired endothelial function and this may be a risk factor for poor cardiovascular health,” the investigators said. “It is unknown if there is an association between lung and endothelial function in the general population.”

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
12 Jan 2020
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.
Stephen Padilla, 5 days ago
The Lancet Commission on Hypertension Group has recently released a position statement that contains a list of recommendations for the improvement of accuracy standards for devices that measure blood pressure (BP).