Most Read Articles
26 Aug 2017
Elderly individuals with high levels of serum uric acid may be at an increased risk of dementia, particularly vascular or mixed dementia, a study suggests.
14 Jan 2016
Tocotrienols are one of the two classes of compounds generally known as vitamin E. Prominent researcher in pharmaceutical technology, Professor Yuen Kah Hay, recently spoke to MIMS Doctor about the neuroprotective benefits conferred by palm tocotrienols. He shared key insights from a clinical trial performed by his team and about the compound’s potential for clinical use.
Elvira Manzano, 01 Feb 2014

There is no benefit to using ibuprofen over paracetamol in most patients with upper respiratory tract infections (URTIs). Steam inhalation therapy also does not offer any advantage, research has shown.

Dr. Joseph Delano Fule Robles, 01 Mar 2017

The tau and Aβ amyloid pathways have emerged as possible novel targets in treating Alzheimer’s disease (AD), according to studies discussed at the recently concluded Hong Kong Pharmacy Conference.

Lower hippocampal volume not related to AD pathology in late-life depression

16 Mar 2017
Sad elderly man contemplating

Lower hippocampal volume is not associated with amyloid pathology, negating the common belief that changes in hippocampal volume in late-life depression are due to prodromal Alzheimer’s disease, according to a recent study.

To investigate the association between lower hippocampal volume in late-life depression and Alzheimer’s disease pathology, a prospective study was conducted involving 100 participants (48 currently depressed older adults and 52 age- and gender-matched healthy comparison participants who underwent structural MRI, flutemetamol (18F) amyloid positron emission tomography imaging, apolipoprotein E genotyping, and neuropsychological assessment).

Hippocampal volumes were manually defined and normalized for total intracranial volume. Researchers quantified amyloid binding using the standardized uptake value ratio in one cortical composite volume of interest. They examined group differences in hippocampal volume, group differences in amyloid uptake and in the proportion of positive amyloid scans, and the association between hippocampal volume and cortical amyloid uptake.

There was a significant difference in mean normalized total hippocampal volume between patients and comparison participants. However, no between-group differences were observed in cortical amyloid uptake or proportion of amyloid-positive participants.

There remained a significant difference in hippocampal volume even after the amyloid-positive participants were excluded. No association existed between hippocampal volume and amyloid uptake in either patients or comparison participants.

“Hippocampal volume is commonly decreased in late-life depression,” researchers said. “According to the depression-as-late-life-neuropsychiatric-disorder model, lower hippocampal volume in late-life depression is associated with neurodegenerative changes.”

A separate study found an association between depression and cognitive impairment. The mechanisms by which depression could induce cognitive impairment were hippocampal atrophy, alterations in glucocorticoid secretion, cerebrovascular compromise, deposition of β-amyloid plaques, chronic inflammation, apolipoprotein E status and deficits of nerve growth factors. [Focus 2017;15:35-41]

Editor's Recommendations
Most Read Articles
26 Aug 2017
Elderly individuals with high levels of serum uric acid may be at an increased risk of dementia, particularly vascular or mixed dementia, a study suggests.
14 Jan 2016
Tocotrienols are one of the two classes of compounds generally known as vitamin E. Prominent researcher in pharmaceutical technology, Professor Yuen Kah Hay, recently spoke to MIMS Doctor about the neuroprotective benefits conferred by palm tocotrienols. He shared key insights from a clinical trial performed by his team and about the compound’s potential for clinical use.
Elvira Manzano, 01 Feb 2014

There is no benefit to using ibuprofen over paracetamol in most patients with upper respiratory tract infections (URTIs). Steam inhalation therapy also does not offer any advantage, research has shown.

Dr. Joseph Delano Fule Robles, 01 Mar 2017

The tau and Aβ amyloid pathways have emerged as possible novel targets in treating Alzheimer’s disease (AD), according to studies discussed at the recently concluded Hong Kong Pharmacy Conference.