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20 Jun 2020
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Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Lower HbA1c prolongs hypoglycaemia duration in type 2 diabetics

14 Sep 2019

In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.

Using a professional-grade continuous glucose monitoring sensor, researchers measured the glucose levels of 300 type 2 diabetes patients (mean age, 69.0±10.7 years; 182 males) who were being treated with sulfonylureas but not insulin. The primary outcome was the duration in hypoglycaemia compared across different categories of HbA1c concentrations, and between night time and daytime.

Participants were categorized according to HbA1c concentrations: 6.4 percent, 6.5–6.9 percent, 7.0–7.4 percent, 7.5–7.9 percent and 8.0 percent. Hypoglycaemia (glucose <54 mg/dL) duration was longer in the lower categories and decreased progressively as HbA1c levels increased (1.6±2.2, 0.6±2.3, 0.4±1.3, 0.5±1.5 and 0.1±0.2 min/h, respectively).

The difference in duration between the ≤6.4-percent and ≥8.0-percent group was statistically significant (p<0.0125).

The trend remained true even when the threshold for hypoglycaemia was moved to <70 mg/dL. The durations for the corresponding HbA1c categories were 6.8±5.6, 2.6±4.1, 1.8±3.2, 1.6±3.3 and 0.4±0.9 min/h. The difference between the bottom and top categories was significant (p<0.0125).

Moreover, researchers found that among those with HbA1c ≤6.4 percent, 6.5–6.9 percent and 7.0–7.4 percent, hypoglycaemia (glucose <54 mg/dL) duration was significantly longer at night vs day (p<0.05). Duration of hypoglycaemia with glucose <70 mg/dL was also significantly longer during the night across all HbA1c categories.

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Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Pearl Toh, 5 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
4 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 3 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.