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Roshini Claire Anthony, 2 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 5 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Jairia Dela Cruz, 6 days ago
Male smokers under the age of 50 years are at risk of developing ischaemic stroke, and this risk increases with the number of cigarettes smoked daily, according to data from the Stroke Prevention in Young Men Study.
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Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

Low vitamin D levels may be detrimental to respiratory health

13 Feb 2018

Decreased serum vitamin D levels appear to confer an increased risk of asthma, bronchitis, wheeze and chest tightness, a study reports. Conversely, increased vitamin D levels are associated with higher levels of lung function.

Researchers examined 5,011 adults (mean age 58 years; 45 percent male), analysing data on serum 25-hydroxyvitamin D (25OHD) and history of respiratory disease. All participants underwent spirometry and completed a questionnaire detailing respiratory symptoms.

Analysis was performed using logistic and linear regression models with adjustments for age, sex, season and smoking (model A), plus body mass index and physical activity level (model B), plus history of chronic diseases (model C).

Of the patients, 10 percent were current smokers and 12 percent were taking vitamin D supplements. The prevalence rate of vitamin D deficiency (25OHD level <50 nmol/L) was 8.0 percent.

All three models showed that participants with 25OHD <50 nmol/L had higher odds of having asthma (model C: odds ratio [OR], 1.32; 95 percent CI, 1.00–1.73), bronchitis (OR, 1.54; 1.17–2.01), wheeze (OR, 1.37; 1.10–1.71) and chest tightness (OR, 1.42; 1.10–1.83).

On the other hand, participants with vitamin D level >100 nmol/L had greater forced vital capacity compared with those who had vitamin D level 50–100 nmol/L group in all the three models (model C: coefficient, 1.17; 0.18–2.15).

The findings indicate that respiratory illness and symptoms are related to lower vitamin D levels, researchers said.

Taken together with evidence from recent studies investigating asthma outcomes and use of vitamin D supplements, the data strengthen the proposed mechanistic relationship between vitamin D deficiency and respiratory disease, they added. [J Allergy Clin Immunol 2017;139:1508-1517; Cochrane Database Syst Rev 2016;9:CD011511]

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Most Read Articles
Roshini Claire Anthony, 2 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 5 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Jairia Dela Cruz, 6 days ago
Male smokers under the age of 50 years are at risk of developing ischaemic stroke, and this risk increases with the number of cigarettes smoked daily, according to data from the Stroke Prevention in Young Men Study.
Yesterday
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.