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Roshini Claire Anthony, 6 days ago

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6 days ago
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Despite the absence of a substance use problem, regular cannabis use is associated with psychosocial impairment among adolescents and young adults, a study suggests. On the other hand, regular users with cannabis use disorder appear to exhibit high psychiatric comorbidity and more severe psychosocial impairment.
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Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.

Low vitamin D levels may be detrimental to respiratory health

13 Feb 2018

Decreased serum vitamin D levels appear to confer an increased risk of asthma, bronchitis, wheeze and chest tightness, a study reports. Conversely, increased vitamin D levels are associated with higher levels of lung function.

Researchers examined 5,011 adults (mean age 58 years; 45 percent male), analysing data on serum 25-hydroxyvitamin D (25OHD) and history of respiratory disease. All participants underwent spirometry and completed a questionnaire detailing respiratory symptoms.

Analysis was performed using logistic and linear regression models with adjustments for age, sex, season and smoking (model A), plus body mass index and physical activity level (model B), plus history of chronic diseases (model C).

Of the patients, 10 percent were current smokers and 12 percent were taking vitamin D supplements. The prevalence rate of vitamin D deficiency (25OHD level <50 nmol/L) was 8.0 percent.

All three models showed that participants with 25OHD <50 nmol/L had higher odds of having asthma (model C: odds ratio [OR], 1.32; 95 percent CI, 1.00–1.73), bronchitis (OR, 1.54; 1.17–2.01), wheeze (OR, 1.37; 1.10–1.71) and chest tightness (OR, 1.42; 1.10–1.83).

On the other hand, participants with vitamin D level >100 nmol/L had greater forced vital capacity compared with those who had vitamin D level 50–100 nmol/L group in all the three models (model C: coefficient, 1.17; 0.18–2.15).

The findings indicate that respiratory illness and symptoms are related to lower vitamin D levels, researchers said.

Taken together with evidence from recent studies investigating asthma outcomes and use of vitamin D supplements, the data strengthen the proposed mechanistic relationship between vitamin D deficiency and respiratory disease, they added. [J Allergy Clin Immunol 2017;139:1508-1517; Cochrane Database Syst Rev 2016;9:CD011511]

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Most Read Articles
Roshini Claire Anthony, 6 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

6 days ago
Patients with coronary artery disease (CAD) treated in a poor Southeast Asian setting appear to have far too high short-term and medium-term mortality rates, according to a study.
Yesterday
Despite the absence of a substance use problem, regular cannabis use is associated with psychosocial impairment among adolescents and young adults, a study suggests. On the other hand, regular users with cannabis use disorder appear to exhibit high psychiatric comorbidity and more severe psychosocial impairment.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.