Most Read Articles
Pearl Toh, Yesterday
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 4 days ago
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.

Low thyroid function tied to mortality in NAFLD

18 Sep 2020

Low thyroid function is associated with nonalcoholic fatty liver disease (NAFLD) and predicts all-cause and cardiovascular mortality in NAFLD patients, suggests a US study.

The authors used the National Health and Nutrition Examination Survey (NHANES) III from 1988 to 1994 and NHANES III-linked mortality data through 2015 for this study, as well as Cox proportional hazard model to analyse the all-cause and cause-specific mortality.

NAFLD was characterized by ultrasonographically diagnosed hepatic steatosis without coexisting liver diseases. Subclinical hypothyroidism was defined as a thyroid-stimulating hormone (TSH) level >4.5 mIU/L and “low-normal” thyroid function as higher TSH level (2.5–4.5 mIU/L) within the euthyroid reference range.

Multivariate logistic regression analysis revealed an association between low thyroid function and NAFLD in a dose-dependent manner. In the univariate model, low thyroid function also correlated with increased all-cause mortality during a median follow-up of 23 years. It was also a predictor of higher risk for all-cause mortality in individuals with NAFLD but not in those without.

In addition, low thyroid function correlated with a higher risk for cardiovascular mortality in the entire population and among those with NAFLD. However, it did not correlate with the non-NAFLD group.

“Higher levels of TSH in the euthyroid state can negatively affect the metabolic health, including NAFLD,” the authors said.

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Most Read Articles
Pearl Toh, Yesterday
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 4 days ago
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.