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Pearl Toh, 22 Oct 2020
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Roshini Claire Anthony, 13 Nov 2020

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Low skeletal muscle mass, sarcopoenic obesity predict albuminuria

21 Apr 2020

Sarcopoenic obesity and low skeletal muscle may increase the risk of albuminuria in the general population, a recent study has shown.

Researchers conducted a retrospective analysis of 29,942 participants (mean age, 49.9±7.9 years; 54 percent male) who had undergone at least two routine examinations from 2006 to 2013. The skeletal muscle mass was measured using bioelectrical impedance, and sarcopoenia was defined as being below the mean of the sex-specific skeletal muscle index (SMI) for a young reference group.

Over the 7-year duration of the study, 981 participants developed albuminuria, yielding an incidence rate of 3.3 percent. The cumulative incidence of albuminuria showed significantly greater increments in those with lower baseline SMI.

Cox proportional hazard regression confirmed that participants in the lowest vs highest tertile of SMI were significantly more likely to develop albuminuria (hazard ratio [HR], 1.44, 95 percent confidence interval [CI], 1.22–1.71). This remained true even after adjusting for general or central obesity.

Sarcopoenia (HR, 1.35, 95 percent CI, 1.09–1.67) and obesity (HR, 1.38, 95 percent CI, 1.15–1.65) were both also separately correlated with the risk of albuminuria. Sarcopoenic obesity, however, emerged as the strongest predictor of albuminuria, conferring a 53-percent greater likelihood relative to comparators who had neither sarcopenia nor obesity (HR, 1.53, 95 percent CI, 1.23–1.91).

“[T]o the best of our knowledge, this is the first report investigating the relationship between sarcopenic obesity as well as relative skeletal muscle mass determined by SMI, and albuminuria development using a large, general population-based 7-year longitudinal dataset,” the researchers said.

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Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Pearl Toh, 6 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Elvira Manzano, 17 Nov 2020
Invasive fungal infections, particularly those caused by Candida species, are common in hospitalized, immunocompromised, or critically ill patients and are associated with considerable morbidity and mortality.