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Rachel Soon, 16 Aug 2019

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Low serum vitamin D, airway obstruction independently predict mortality

02 Aug 2019

Airway obstruction and low serum 25-hydroxyvitamin-D (s-25[OH]D) are independent predictors of mortality in adults, suggest the results of a 33-year follow-up study.

Multivariable analysis adjusted for age, sex, smoking, education, body mass index, leisure physical activity, asthma and serum C-reactive protein revealed the independent association of obstruction and low s-25(OH)D with mortality.

On the other hand, a statistically significant interaction was found between mortality and low s-25(OH)D among patients without (adjusted mortality hazard ratios [HR] for s-25(OH)D in tertiles, 1.00 [lowest]; 0.96, 95 percent CI, 0.87–1.05; 0.89, 0.81–0.98) and with obstruction (adjusted HR, 1.00; 0.96, 0.71–1.31; 0.57, 0.40–0.80).

An earlier study involving 13,331 adults from the Third National Health and Nutrition Examination Survey also found that the lowest quartile of 25(OH)D level was independently associated with all-cause mortality in the general population. [Arch Intern Med 2008;168:1629-1637]

“In conclusion, obstruction and low s-25(OH)D predict mortality independently of each other,” the authors said. “Our findings suggest that low vitamin D status might be particularly detrimental among [patients] with obstruction.”

This study investigated a joint effect of airway obstruction and vitamin D status on mortality by analysing data of 6,676 Finnish adults participating between 1978 and 1980 in a national health examination survey, undergoing spirometry and having all necessary data collected.

Participants were followed up in national registers through record linkage until 31 December 2011. Those with airway obstruction were categorized using the lower limit of normal and the measured s-25(OH)D into tertiles.

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Most Read Articles
Rachel Soon, 16 Aug 2019

On 8 August, the first town hall held by the Ministry of Health (MOH) with members of the pharmacy profession took place in Putrajaya. Over 500 pharmacists from across the country and from different areas of practice—community and hospital, public and private, academy and industry—converged to fill the auditorium for the chance to engage in direct dialogue with MOH.

3 days ago
Cardiac biomarkers are useful for identifying community-acquired pneumonia (CAP) patients with an elevated risk of early and long-term cardiovascular (CV) events, according to a study.
Yesterday
Tofogliflozin is safe and effective for elderly patients with type 2 diabetes mellitus (T2DM), regardless of insulin and oral antidiabetic drugs, reports a new Japan study.
6 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.