Most Read Articles
Pearl Toh, 3 days ago
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 5 days ago
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.

Low saturated fatty acid intake predicts arterial stiffness in diabetics

24 Jul 2020

Lower consumption levels of saturated fatty acids (SFAs) are tied to elevated brachial-ankle pulse wave velocity (baPWV) in patients with type 2 diabetes, a new study reports.

The study included 733 patients (mean age, 57.8±8.6 years; 63.1 percent male) with type 2 diabetes who had no apparent history of cardiovascular diseases. A self-administered diet history questionnaire was used to determine dietary schedule, and baPWV was measured at baseline and at years 2 and 5 using an automatic waveform analyzer.  

Participants logged a mean total daily energy intake of 1,719 kcal per day, most of which were derived from carbohydrates (53 percent). SFAs comprised 7 percent of the overall average daily energy intake.

Over 5 years of follow-up, researchers recorded slight but significant increase in glycated haemoglobin levels. Similarly, modest but statistically relevant changes in body mass index, systolic and diastolic blood pressure, and triglyceride and high-density lipoprotein levels were observed. Of note, baPWV also increased significantly over the follow-up period.

Linear mixed-effects modelling discovered a significant and inverse correlation between total calorie intake from SFAs and baPWV (regression coefficient per unit decrease in SFA intake, –1,614.4±520.8; p=0.002).

Low SFA calorie intake remained a significant correlate of persistently higher baPWV even after controlling for dietary nutrient intake and conventional atherosclerotic factors.

Dividing the participants into tertiles of SFA calories further reinforced the primary findings. Those who drew ≥7.4 percent of their total calories from SFAs consistently showed lower baPWV than their comparators who obtained <5.8 percent of the total calories from SFAs.

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Most Read Articles
Pearl Toh, 3 days ago
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 5 days ago
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.