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Low-salt, high-potassium diet yields BP reductions in normotensive women

12 Apr 2018

In drug-naïve normotensive individuals, the beneficial effects of a low-salt, high-potassium diet on blood pressure (BP) are more pronounced in women than men, a study reports.

Researchers analysed the estimated 24-hour urinary sodium and potassium excretion rate in 3,392 drug-naïve Japanese individuals with normal BP (average age 48.4 years) in relation to their BP levels. Known risk factors to salt sensitivity, such as age, body mass index, serum creatinine, homeostasis model assessment of insulin resistance (IR) and urinary potassium excretion, were included as potential confounders.

In multivariate regression models, a 10-mmol/day increment in urinary sodium excretion was associated with an increase in systolic BP of 0.16 mm Hg in men and 0.37 mm Hg in women.

In terms of urinary potassium excretion, a 10-mmol/day increment was associated with a reduction in systolic BP of −0.54 mm Hg in men and −1.49 mm Hg in women. Moreover, the involvement of IR on BP was seen only in women.

Findings of the present study highlight the importance of sodium restriction and increased potassium intake, as well as maintaining an appropriate balance, to prevent BP elevation or the new onset of hypertension and its complications not only in hypertensive patients but also in drug-naïve normotensive individuals, especially in women.

Researchers explained that renal potassium handling relates to sodium handling, and a lower potassium diet may enhance sodium reabsorption along the distal convolute tubule, via the upregulation of thiazide-sensitive sodium chloride co-transporter. [Kidney Dis 2016;2:72-79]

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Most Read Articles
Pearl Toh, 3 days ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
6 days ago
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Pearl Toh, 07 Dec 2018
Apixaban slashes the risk of recurrent venous thromboembolism (VTE) by 90 percent in cancer patients compared with the low-molecular-weight heparin (LMWH) dalteparin, with no increase in major bleeding risk, according to the ADAM VTE study presented at ASH 2018.
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