Most Read Articles
KY Leung, 01 Feb 2014

Group B Streptococcus (GBS) is the commonest cause of severe early-onset neonatal infection, which is associated with a high rate of morbidity and mortality (5–10%).1-3 About half of GBS meningitis will be complicated by neurodevelopment impairment. Because the early-onset disease develops shortly and rapidly after birth, there has been little improvement in the disease treatment, and the focus thus lies in disease prevention.

Jairia Dela Cruz, 23 Oct 2017
Evacuation proctography, magnetic resonance imaging, and transperineal and endovaginal ultrasonography demonstrate similar diagnostic test accuracy for posterior pelvic floor disorders in women with obstructed defecation syndrome, a recent study has shown.
Dr. Joseph Delano Fule Robles, 14 Oct 2016

Results of a recent clinical trial showed that treatment with niraparib, a poly ADP ribose polymerase (PARP) inhibitor,  improved progression-free survival (PFS) by more than 15 months in patients with recurrent ovarian cancer responding to platinum. 

Low rate of DRMs, vertical transmission of HIV-1 among women treated with Option B+

14 Jul 2017
The 2012 WHO guidelines recommend the initiation of lifelong antiretroviral combination therapy for all pregnant HIV-1 positive women in resource-limited settings regardless of their CD4 count or clinical stage to prevent mother-to-child transmission of HIV-1 (Option B+). There has been some concern that such programmes may encourage the development of drug resistance mutations (DRMs), but a recent study has shown that the risk of drug resistance is low.

A total of 124 HIV-1 positive pregnant women in Fort Portal, Uganda, were enrolled in the study. Blood samples were collected at their first visit to the antenatal clinic before initiating Option B+ as well as at 6 weeks and 6, 12, and 18 months postpartum. Viral load was determined by real-time RT-PCR and analyses were also made of vertical transmission. A total of 49 women (39.5 percent) were also included in a DRM analysis. Virological failure was defined as >1,000 copies HIV-1 RNA/mL.

At 1-year postpartum, three women were found to have virological failure, and seven were affected by the 18-month time point. No vertical transmission of HIV-1 was noted among the 49 mother-infant pairs included in the DRM analysis. However, three women had developed DRMs, and two had dual-class resistance against all recommended first-line drugs.

The researchers suggested that their findings of a low DRM selection rate support the continued adoption of the Option B+ for preventing mother-to-child transmission of HIV-1.
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Most Read Articles
KY Leung, 01 Feb 2014

Group B Streptococcus (GBS) is the commonest cause of severe early-onset neonatal infection, which is associated with a high rate of morbidity and mortality (5–10%).1-3 About half of GBS meningitis will be complicated by neurodevelopment impairment. Because the early-onset disease develops shortly and rapidly after birth, there has been little improvement in the disease treatment, and the focus thus lies in disease prevention.

Jairia Dela Cruz, 23 Oct 2017
Evacuation proctography, magnetic resonance imaging, and transperineal and endovaginal ultrasonography demonstrate similar diagnostic test accuracy for posterior pelvic floor disorders in women with obstructed defecation syndrome, a recent study has shown.
Dr. Joseph Delano Fule Robles, 14 Oct 2016

Results of a recent clinical trial showed that treatment with niraparib, a poly ADP ribose polymerase (PARP) inhibitor,  improved progression-free survival (PFS) by more than 15 months in patients with recurrent ovarian cancer responding to platinum.