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Low pregnancy-associated plasma protein-A levels up risk of pre-eclampsia

13 Feb 2018
It was speculated that the family’s wish for a second child in a short period of time might be the reason why they allegedly refused permission for a C-section delivery.

Low serum levels of pregnancy-associated plasma protein-A (PAPP-A) appears to increase the risk of early development pre-eclampsia, a recent study has shown.

The researchers performed a cohort study on 3,663 pregnant females with singleton pregnancies undergoing screening for foetal Down syndrome. In the cohort, 357 had low PAPP-A and were designated as the study group, while the remaining 3,306 were identified as controls. Maternal weight was significantly higher in the study vs control group (58.0±9.6 vs 53.5±8.0 kg; p<0.001).

In terms of pre-eclampsia, the prevalence rate was significantly higher in the study group compared with the control group (8.4 vs 2.6 percent; p<0.0001). Early-onset pre-eclampsia was also significantly more common in the study group (1.1 vs 0.1 percent; p=0.0016). The respective overall rates were 3.1 and 0.2 percent.

Risk analysis showed the same results. Those with lower serum PAPP-A levels had significantly elevated risks of pre-eclampsia (relative risk [RR], 3.27; 95 percent CI, 2.19–4.88) and early-onset pre-eclampsia (RR, 9.26; 2.33–36.87).

Low PAPP-A concentrations showed acceptable diagnostic indices, with a sensitivity of 26.1 percent and a specificity of 90.8 percent. The positive and negative predictive values were calculated to be 8.4 percent and 97.4 percent, respectively.

Decreased vs normal PAPP-A levels were also associated with other adverse birth outcomes, such as low birth weight (2,746±945 vs 3,035±526 g; p<0.001), stillbirth (9.5 percent vs 1.3 percent; p<0.0001), low Apgar scores (p<0.0001), preterm birth (16.2 percent vs 8.0 percent; p<0.0001) and foetal growth restrictions (10.9 percent vs 6.5 percent; p=0.002).

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Most Read Articles
2 days ago
No association exists between physical activity and the risk of urological cancer, according to a population-based prospective study in Japan.
12 Feb 2019
Olanzapine confers a modest therapeutic effect on weight compared with placebo in adult outpatients with anorexia nervosa, a study has shown. However, it does not appear to offer significant benefit for psychological symptoms.
3 days ago
Patients with childhood-onset inflammatory bowel disease are more likely to die than the general population, a study suggests.
3 days ago
Reduced caloric intake results in a significant improvement in glucose metabolism and body-fat composition, including liver-fat content, according to a study. Changes in ferritin levels appear to mediate the striking reduction in liver fat.