Most Read Articles
Roshini Claire Anthony, 2 days ago

A subgroup of patients with HBeAg-negative chronic hepatitis B virus (HBV) infection who ceased their long-term nucleotide analogue treatment maintained virological suppression, pointing to a group of patients who may be suitable for treatment cessation, according to a recent study.

Rachel Soon, 4 days ago

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

3 days ago
Higher cancer symptom burden in elderly adults is associated with functional impairment, reports a recent study.
Jairia Dela Cruz, 6 days ago
Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.

Low night diastolic ocular perfusion pressure ups risk of normal tension glaucoma progression

02 Aug 2018
A GP who misdiagnosed a patient’s glaucoma - leading to her partial loss of vision - has been suspended by the SMC.

Low nocturnal diastolic ocular perfusion pressure (DOPP) is an independent predictor of normal tension glaucoma (NTG) progression, a recent study has found.

Researchers followed for 5 years 65 NTG patients (mean age at follow-up 68.2±9.8 years; 50.8 percent female) with baseline 24-hour intraocular pressure and blood pressure (BP) measurements. The modified Anderson criteria was used to assess disease progression, while Cox proportional hazards models were used to determine the relevant risk factors.

Over a mean follow-up time of 6.0±0.7 years, the disease progressed in 35.4 percent of the eyes (n=23) and the mean rate of global visual field (VF) change was –0.70±1.16 dB per year.

In terms of systemic BP parameters, mean daytime (75.90±10.16 vs 80.35±8.94 mm Hg; p=0.038), evening (75.54±6.90 vs 80.37±8.75; p=0.0080) and night (70.30±9.58 vs 75.82±6.82; p=0.009) diastolic BPs were significantly lower in those whose disease progressed. No between-group differences were observed in terms of systolic BP and mean arterial pressure.

Multivariable analysis revealed that low nocturnal DOPP at baseline was associated with a significantly elevated risk of glaucomatous VF progression at follow-up, such that each unit drop in night time DOPP increased the risk of progression by 1.4 times (hazard ratio [HR], 0.71; 95 percent CI, 0.55–0.93; p=0.012).

Baseline pattern standard deviation was likewise a significant predictor of progression, wherein each unit increase in baseline values was associated with a 14-percent increase in the risk of disease progression (HR, 1.14; 1.00–1.29; p=0.05).

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 2 days ago

A subgroup of patients with HBeAg-negative chronic hepatitis B virus (HBV) infection who ceased their long-term nucleotide analogue treatment maintained virological suppression, pointing to a group of patients who may be suitable for treatment cessation, according to a recent study.

Rachel Soon, 4 days ago

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

3 days ago
Higher cancer symptom burden in elderly adults is associated with functional impairment, reports a recent study.
Jairia Dela Cruz, 6 days ago
Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.