Most Read Articles
Roshini Claire Anthony, 5 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

10 Aug 2018

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 6 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.

Low night diastolic ocular perfusion pressure ups risk of normal tension glaucoma progression

02 Aug 2018
A GP who misdiagnosed a patient’s glaucoma - leading to her partial loss of vision - has been suspended by the SMC.

Low nocturnal diastolic ocular perfusion pressure (DOPP) is an independent predictor of normal tension glaucoma (NTG) progression, a recent study has found.

Researchers followed for 5 years 65 NTG patients (mean age at follow-up 68.2±9.8 years; 50.8 percent female) with baseline 24-hour intraocular pressure and blood pressure (BP) measurements. The modified Anderson criteria was used to assess disease progression, while Cox proportional hazards models were used to determine the relevant risk factors.

Over a mean follow-up time of 6.0±0.7 years, the disease progressed in 35.4 percent of the eyes (n=23) and the mean rate of global visual field (VF) change was –0.70±1.16 dB per year.

In terms of systemic BP parameters, mean daytime (75.90±10.16 vs 80.35±8.94 mm Hg; p=0.038), evening (75.54±6.90 vs 80.37±8.75; p=0.0080) and night (70.30±9.58 vs 75.82±6.82; p=0.009) diastolic BPs were significantly lower in those whose disease progressed. No between-group differences were observed in terms of systolic BP and mean arterial pressure.

Multivariable analysis revealed that low nocturnal DOPP at baseline was associated with a significantly elevated risk of glaucomatous VF progression at follow-up, such that each unit drop in night time DOPP increased the risk of progression by 1.4 times (hazard ratio [HR], 0.71; 95 percent CI, 0.55–0.93; p=0.012).

Baseline pattern standard deviation was likewise a significant predictor of progression, wherein each unit increase in baseline values was associated with a 14-percent increase in the risk of disease progression (HR, 1.14; 1.00–1.29; p=0.05).

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Most Read Articles
Roshini Claire Anthony, 5 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

10 Aug 2018

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 6 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.