Most Read Articles
21 hours ago
Use of potassium citrate and thiazides appears to improve health-related quality of life (HRQOL) among stone formers across all Wisconsin Stone Quality of Life (WISQOL) domains without increasing the likelihood of gastrointestinal complaints and fatigue or sexual complaints, respectively, reports a study.
Pearl Toh, 4 days ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
2 days ago
Eating high amounts of red and processed meat prior to a diagnosis of colorectal cancer appears to be associated with shorter survival time, although a possible weak association cannot be excluded, a study has shown.
Yesterday
Middle-aged Caucasian men who are dissatisfied with their marriage are at higher risk of sudden cardiac death regardless of other cardiovascular risk factors, a new study reports.

Low night diastolic ocular perfusion pressure ups risk of normal tension glaucoma progression

02 Aug 2018
A GP who misdiagnosed a patient’s glaucoma - leading to her partial loss of vision - has been suspended by the SMC.

Low nocturnal diastolic ocular perfusion pressure (DOPP) is an independent predictor of normal tension glaucoma (NTG) progression, a recent study has found.

Researchers followed for 5 years 65 NTG patients (mean age at follow-up 68.2±9.8 years; 50.8 percent female) with baseline 24-hour intraocular pressure and blood pressure (BP) measurements. The modified Anderson criteria was used to assess disease progression, while Cox proportional hazards models were used to determine the relevant risk factors.

Over a mean follow-up time of 6.0±0.7 years, the disease progressed in 35.4 percent of the eyes (n=23) and the mean rate of global visual field (VF) change was –0.70±1.16 dB per year.

In terms of systemic BP parameters, mean daytime (75.90±10.16 vs 80.35±8.94 mm Hg; p=0.038), evening (75.54±6.90 vs 80.37±8.75; p=0.0080) and night (70.30±9.58 vs 75.82±6.82; p=0.009) diastolic BPs were significantly lower in those whose disease progressed. No between-group differences were observed in terms of systolic BP and mean arterial pressure.

Multivariable analysis revealed that low nocturnal DOPP at baseline was associated with a significantly elevated risk of glaucomatous VF progression at follow-up, such that each unit drop in night time DOPP increased the risk of progression by 1.4 times (hazard ratio [HR], 0.71; 95 percent CI, 0.55–0.93; p=0.012).

Baseline pattern standard deviation was likewise a significant predictor of progression, wherein each unit increase in baseline values was associated with a 14-percent increase in the risk of disease progression (HR, 1.14; 1.00–1.29; p=0.05).

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
21 hours ago
Use of potassium citrate and thiazides appears to improve health-related quality of life (HRQOL) among stone formers across all Wisconsin Stone Quality of Life (WISQOL) domains without increasing the likelihood of gastrointestinal complaints and fatigue or sexual complaints, respectively, reports a study.
Pearl Toh, 4 days ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
2 days ago
Eating high amounts of red and processed meat prior to a diagnosis of colorectal cancer appears to be associated with shorter survival time, although a possible weak association cannot be excluded, a study has shown.
Yesterday
Middle-aged Caucasian men who are dissatisfied with their marriage are at higher risk of sudden cardiac death regardless of other cardiovascular risk factors, a new study reports.