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Low lean mass predicts fracture risk in Korean males

06 Aug 2017

Low lean mass (LM), either alone or in combination with high percentage fat mass (PF), increases the risk of fragility in Korean males, a new study shows. In Korean females, body composition does not appear to be associated with fracture risk.

Body compositions of 2,189 males and 2,625 females from the Ansung cohort study were measured using bioelectrical impedance analysis. Self-reported questionnaires were used to assess fractures excluding high-trauma fractures. Patients with malignancies or who had taken drugs that may have affected bone metabolism were excluded.

Over a follow-up period of 9.4 years, 3.5 percent (n=77) of male and 7.7 percent (n=203) of female participants had fractures.

Compared with males without fractures, weight (65.4±9.9 vs 61.2±8.8 kg; p<0.001), BMI (23.8±3.0 vs 22.2±2.8 kg/m2; p<0.001), LM (48.6±6.5 vs 46.1±6.5 kg; p=0.001) and fat mass (13.9±5.1 vs 12.4±4.6 kg; p=0.009) were all significantly lower in males with fractures.

Females with fractures had significantly lower height (55.1±9.0 vs 59.2±7.5 cm; p<0.001) and LM (37.6±4.7 vs 36.5±4.1 kg; p=0.001) than females with fractures.

Compared with males with normal LM and PF, males with low LM and normal PF (hazard ratio [HR], 2.16; 95 percent CI, 1.13 to 4.16) and those with low LM and high PF (HR, 2.59; 1.13 to 5.95) had higher risk of fractures. Males with normal LM and high PF did not have an elevated risk of fractures (HR, 0.71; 0.38 to 1.31).

The risk of fractures in females with low LM and normal PF (HR, 1.14; 0.72 to 1.79), with low LM and high PF (HR, 1.03; 0.49 to 2.19), and with normal LM and high PF (HR, 1.33; 0.95 to 1.87) were only slightly higher than those with normal LM and PF.

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Most Read Articles
11 Dec 2017
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, 4 days ago
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
6 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.
01 Dec 2017
At a symposium during the 25th Congress of the Obstetrical and Gynaecological Society of Malaysia in Kuala Lumpur, Professor Susan Davis discussed the unique implications of women living decades beyond menopause, and how healthcare professionals can best manage menopausal symptoms in the short and long term.