Low-fat, high-cholesterol diet better for weight loss
In a Chinese population, consumption of low-fat, high-cholesterol diets is less likely to result in excessive weight gain and worse cardiometabolic risk profiles as compared with high-fat, low-cholesterol diets, a new randomized controlled-feeding trial shows.
The study included 307 healthy adults aged between 18 and 35 years and with body mass index (BMI) <28. Participants were then randomized to receive one of three isocaloric diets: low-fat, high-carbohydrate (n=101), moderate-fat and carbohydrate (n=105), and high-fat, low-carbohydrate (n=101).
Participants were instructed to avoid excessive exercise during the study period and were made to strictly follow one of the three prescribed diets. The primary outcome was body weight measured every month.
The mean baseline BMI for the low-fat, moderate-fat and high-fat diet groups were 21.7, 21.8 and 21.9 kg/m2. The reported rates of adherence to the diets were high (93 to 98 percent), as were the level of satisfaction (8 to 8.5).
While all dietary groups lost weight over the course of the study, the weight loss was significantly greater in the low-fat diet group vs the moderate- and high-fat diet groups (p<0.001 for interaction).
Similarly, waist circumference reductions were observed in all groups, with the low-fat diet group showing the highest reductions (p<0.0001 for interaction)
Of the 245 participants whocompleted the study, the overall changes in weight were -1.6 (95 percent CI, -1.7 to -1.4) kg for the low-fat diet group, -1.1 (-1.3 to -0.8) kg for the moderate-fat group and -1.0 (-1.3 to -0.7) for the high-fat group.