Most Read Articles
29 Apr 2016
This article presents the excerpts from the Inaugural Meeting of the Dementia Advisory Board Malaysia held on 23 January 2016 in Kuala Lumpur, highlighting the clinical evidence of Ginkgo biloba extract EGb761® in dementia, treatment recommendations from international guidelines and consensus reached during the meeting on the role of EGb761® in managing dementia.
Christina Lau, 23 Nov 2018

Use of a ginkgo biloba extract on top of standard preventive treatment is shown to improve cognitive function and overall condition after acute ischaemic stroke.

Low-dose haloperidol ineffective against delirium following thoracic surgery

4 days ago

Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.

Researchers randomly assigned 135 adults undergoing thoracic surgery to receive either low-dose intravenous haloperidol (0.5 mg thrice daily, 11 total doses; n=68; median age 60 years; 32.4 percent female) or placebo (n=67; median age 62.3 years; 19.4 percent female).

The incidence of delirium was statistically comparable between the haloperidol and placebo groups (22.1 percent vs 28.4 percent; p=0.43). Similarly, there were no significant differences in the time to development of delirium (p=0.43) or the median number of delirium days (p=0.71).

Both groups also showed similar median lengths of stay in the intensive care unit (ICU; haloperidol vs placebo: 2.2 vs 2.3 days; p=0.29) and in the hospital (10 vs 10 days; p=0.40). However, when analysis was restricted to only those with delirium, haloperidol resulted in a significantly shorter median hospital stay (10 vs 11 days; p=0.03).

Researchers then conducted a subgroup analysis on 84 patients undergoing oesophagectomy, of whom 42 received the haloperidol intervention while 42 were given placebo. In these patients, haloperidol demonstrated superiority over placebo at reducing delirium incidence (23.8 percent vs 40.5 percent), but the difference did not reach statistical significance (p=0.16).

Most of the secondary outcomes were similarly comparable: time to delirium (p=0.14), number of days with delirium (p=0.70) and length of hospital stay (p=0.25). In contrast, oesophagectomy patients on haloperidol showed significantly shorter median lengths of ICU stay (2.8 vs 3.1 days; p=0.03).

Editor's Recommendations
Most Read Articles
29 Apr 2016
This article presents the excerpts from the Inaugural Meeting of the Dementia Advisory Board Malaysia held on 23 January 2016 in Kuala Lumpur, highlighting the clinical evidence of Ginkgo biloba extract EGb761® in dementia, treatment recommendations from international guidelines and consensus reached during the meeting on the role of EGb761® in managing dementia.
Christina Lau, 23 Nov 2018

Use of a ginkgo biloba extract on top of standard preventive treatment is shown to improve cognitive function and overall condition after acute ischaemic stroke.