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Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

Low-dose dopamine does not affect renal function in cytarabine-administered patients

05 Oct 2017

Variations exist among patients who received low-dose dopamine, but overall use of the said drug does not have a significant impact on renal function, according to a study. In addition, low-dose dopamine shows no adverse effect on cardiovascular (CV) function.

Researchers performed a retrospective, single-centre, cohort study of patients receiving cytarabine at 667 mg/m2/dose or greater, with or without dopamine at ≤5 mcg/kg/min, to evaluate changes in renal function, CV adverse events and neurologic toxicity in these individuals. Cohorts were based upon initiation or absence of low-dose dopamine: cytarabine only, cytarabine + pre- and day of low-dose dopamine, and cytarabine + post-low-dose dopamine.

Researchers compared renal outcomes (urine output, serum creatinine and creatinine clearance) with baseline and between cohorts. Safety endpoints (arrhythmias, tachycardia and neurotoxicity) were also compared between cohorts based on exposure to low-dose dopamine.

No difference was observed in urine output from baseline in all cohorts. There was no difference in urine output between cytarabine only and pre- and day of low-dose dopamine cohorts. Also, serum creatinine and creatinine clearance were not different from baseline among patients receiving low-dose dopamine.

During the study period, there were arrhythmias recorded, and there was no between-group difference in the incidence of tachycardia (p=0.06). Three patients administered low-dose dopamine had neurotoxicity.

“Low-dose dopamine has been utilized to improve renal blood flow, urine output and reduce drug-induced nephrotoxicity,” researchers noted.

A meta-analysis by Friedrich and colleagues found that low-dose dopamine provided transient improvement in renal physiology. However, there was no good evidence showing that it offers significant clinical benefits to patients with or at risk for acute renal failure. [Ann Intern Med 2005;142:510-24]

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Most Read Articles
2 days ago
Dairy consumption during adolescence or early adulthood does not appear to be associated with the overall risk of breast cancer, although results vary by hormone receptor status of tumours, a study has shown. Specifically, dairy intake is linked to higher ER–/PR– and lower ER+/PR+ cancer risk.
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The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

3 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
4 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.