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Low creatinine tied to diabetes risk

21 Apr 2019

There appears to be a link between low serum creatinine levels and a higher risk of diabetes, a recent study has shown.

The study included 31,343 male workers without diabetes at baseline (aged 20–64 at baseline), in whom the cumulative average of serum creatinine levels was collected over the course of the study. Diabetes was defined as fasting glucose levels ≥126 mg/dL, glycated haemoglobin ≥6.5 percent, random glucose levels ≥200 mg/dL or use of antidiabetic treatment.

Over a median observation period of 7.7 years, 2,509 participants developed diabetes, resulting in a crude incidence rate of 12.3 per 1,000 person-years. After adjusting for worksite and age, men with <0.70 mg/dL of serum creatinine were significantly more likely to develop diabetes than those with 0.9–1.2 mg/dL (hazard ratio [HR], 1.39; 95 percent CI, 1.18–1.58; ptrend<0.001).

This interaction was further pronounced after additional adjustments for dyslipidaemia, smoking, hypertension and body mass index (BMI; HR, 1.56; 1.35–1.82). The effect of low serum creatinine (<70 vs 0.90–1.20 mg/dL) was also significant in those with prediabetes at baseline (HR, 1.45; 1.23–1.70; ptrend<0.001).

In stratified analysis, researchers found that the effect of serum creatinine was significantly stronger in older vs younger adults (p=0.001). On the other hand, BMI, hypertension, smoking and dyslipidaemia did not appear to exert such a modifying effect.

“Screening serum creatinine levels can be used to identify those at a high risk of diabetes,” said researchers.

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Most Read Articles
3 days ago
Monotherapy with tenofovir disoproxil fumarate increases virologic response for up to 240 weeks in pretreated patients with hepatitis B virus infection (HBV) who are resistant to entecavir and/or adefovir, a new study has found.
Elvira Manzano, 3 days ago
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Pearl Toh, 21 hours ago
Patients with rheumatoid arthritis (RA) who maintained their disease remission had a significantly reduced risk of clinical and subclinical atherosclerosis, according to the 3-year follow-up data of the GIRRCS* study presented at EULAR 2019.
2 days ago
Duodenal eosinophilia carries up to a sixfold increased risk of developing gastro-oesophageal reflux disease (GERD) over 10 years in individuals with functional dyspepsia (FD) and postprandial distress syndrome (PDS), a study has found.