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Low creatinine tied to diabetes risk

21 Apr 2019

There appears to be a link between low serum creatinine levels and a higher risk of diabetes, a recent study has shown.

The study included 31,343 male workers without diabetes at baseline (aged 20–64 at baseline), in whom the cumulative average of serum creatinine levels was collected over the course of the study. Diabetes was defined as fasting glucose levels ≥126 mg/dL, glycated haemoglobin ≥6.5 percent, random glucose levels ≥200 mg/dL or use of antidiabetic treatment.

Over a median observation period of 7.7 years, 2,509 participants developed diabetes, resulting in a crude incidence rate of 12.3 per 1,000 person-years. After adjusting for worksite and age, men with <0.70 mg/dL of serum creatinine were significantly more likely to develop diabetes than those with 0.9–1.2 mg/dL (hazard ratio [HR], 1.39; 95 percent CI, 1.18–1.58; ptrend<0.001).

This interaction was further pronounced after additional adjustments for dyslipidaemia, smoking, hypertension and body mass index (BMI; HR, 1.56; 1.35–1.82). The effect of low serum creatinine (<70 vs 0.90–1.20 mg/dL) was also significant in those with prediabetes at baseline (HR, 1.45; 1.23–1.70; ptrend<0.001).

In stratified analysis, researchers found that the effect of serum creatinine was significantly stronger in older vs younger adults (p=0.001). On the other hand, BMI, hypertension, smoking and dyslipidaemia did not appear to exert such a modifying effect.

“Screening serum creatinine levels can be used to identify those at a high risk of diabetes,” said researchers.

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Most Read Articles
6 days ago
In patients with type 2 diabetes, obesity may be protective against vision-threatening diabetic retinopathy, a recent Korea study has shown.
Yesterday
The aromatase inhibitor anastrozole shows promise in the treatment of children with congenital adrenal hyperplasia, reducing bone age advancement without adversely affecting bone mineral density and visceral adipose tissue, as shown in a recent study.
Roshini Claire Anthony, 5 days ago

Men with metastatic hormone-sensitive prostate cancer (mHSPC) who receive testosterone suppression therapy may have a better survival outcome with the addition of enzalutamide over other non-steroidal anti-androgen (NSAA) therapies, according to the phase III ENZAMET* trial.

5 days ago
The use of opioids may have limited long-term efficacy in the management of chronic noncancer pain, reports a new study.