Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 3 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 4 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
14 Sep 2019
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.

Low creatinine tied to diabetes risk

21 Apr 2019

There appears to be a link between low serum creatinine levels and a higher risk of diabetes, a recent study has shown.

The study included 31,343 male workers without diabetes at baseline (aged 20–64 at baseline), in whom the cumulative average of serum creatinine levels was collected over the course of the study. Diabetes was defined as fasting glucose levels ≥126 mg/dL, glycated haemoglobin ≥6.5 percent, random glucose levels ≥200 mg/dL or use of antidiabetic treatment.

Over a median observation period of 7.7 years, 2,509 participants developed diabetes, resulting in a crude incidence rate of 12.3 per 1,000 person-years. After adjusting for worksite and age, men with <0.70 mg/dL of serum creatinine were significantly more likely to develop diabetes than those with 0.9–1.2 mg/dL (hazard ratio [HR], 1.39; 95 percent CI, 1.18–1.58; ptrend<0.001).

This interaction was further pronounced after additional adjustments for dyslipidaemia, smoking, hypertension and body mass index (BMI; HR, 1.56; 1.35–1.82). The effect of low serum creatinine (<70 vs 0.90–1.20 mg/dL) was also significant in those with prediabetes at baseline (HR, 1.45; 1.23–1.70; ptrend<0.001).

In stratified analysis, researchers found that the effect of serum creatinine was significantly stronger in older vs younger adults (p=0.001). On the other hand, BMI, hypertension, smoking and dyslipidaemia did not appear to exert such a modifying effect.

“Screening serum creatinine levels can be used to identify those at a high risk of diabetes,” said researchers.

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Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 3 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 4 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
14 Sep 2019
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.