Most Read Articles
22 hours ago
There appears to be a high rate of emergency department (ED) admission for acute exacerbation of chronic obstructive pulmonary disease (AECOPD), with patients having significant in-hospital mortality, according to data from the *AANZDEM study. Furthermore, compliance with evidence-based treatments in the ED is suboptimal.
Tristan Manalac, 5 days ago
Of the newly identified genetic loci for primary angle-closure glaucoma (PACG), two are significantly associated with primary angle-closure suspect (PACS), indicating involvement in the earlier stages of the disease, a recent Singapore study has shown.
2 days ago
Resistance training appears to confer significant benefits for inflammation and insulin pathway profiles in postmenopausal breast cancer survivors, according to a study. However, the magnitude and degree of benefit from exercise may be influenced by whether or not women gained strength and/or lost weight during exercise.
Pearl Toh, 2 days ago
Patients with inflammatory bowel disease (IBD) who had primary nonresponse to an anti-tumour necrosis factor (TNF) agent ─ or inadequate response to the initial loading doses ─ were less likely to respond to second-line biologics compared with those who had secondary loss of response (LOR) or intolerance to the primary therapy, according to a systematic review and meta-analysis presented at the Crohn's & Colitis Congress (CCC) 2018 held recently in Las Vegas, Nevada, US.

Low-cost Aurolab aqueous drainage implant safe, effective for refractory childhood glaucoma

05 Dec 2017

The effectiveness and safety profile of Aurolab aqueous drainage implant (AADI) are similar with published reports of the Baerveldt glaucoma implant (BGI) and Ahmed glaucoma valve implant in patients with refractory childhood glaucoma, making AADI a viable low-cost glaucoma drainage device (GDD), reports a recent study.

The investigators conducted a prospective interventional study in a tertiary care postgraduate teaching institute to assess the safety and efficacy of AADI, recruiting 31 children aged <16 years with uncontrolled intraocular pressure (IOP) refractory to medical treatment and considered at high risk of failure following trabeculectomy.

AADI was implanted to eligible children. Included in the analysis were those who completed a minimum of 6-month follow-up. Main clinical outcomes were IOP reduction from preoperative values and postoperative complications. A total of 34 eyes were analysed, with average follow-up of 18.3 months.

On maximum medication, mean IOP decreased from 27.4 mm Hg to 14.6 mm Hg at 1 week, 13.8 mm Hg at 6 months, 12.8 mm Hg, at 1 year (32 eyes of 29 children) and 14.7 mm Hg at 2 years (25 eyes of 22 children) postoperatively (p<0.001). The cumulative probability of success was 91.18 percent at 6 months and 81.7 percent at 18 to 24 months.

Mean number of topical medications dropped from 3.1 to 1.8 and 1.6 at 6 and 24 months, respectively (p<0.001). There were 25 patients who needed systemic acetazolamide preoperatively, decreasing to three patients at 2 years.

In addition, no tube erosion or infection was reported among patients. However, one eye developed retinal detachment, according to the investigators.

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Most Read Articles
22 hours ago
There appears to be a high rate of emergency department (ED) admission for acute exacerbation of chronic obstructive pulmonary disease (AECOPD), with patients having significant in-hospital mortality, according to data from the *AANZDEM study. Furthermore, compliance with evidence-based treatments in the ED is suboptimal.
Tristan Manalac, 5 days ago
Of the newly identified genetic loci for primary angle-closure glaucoma (PACG), two are significantly associated with primary angle-closure suspect (PACS), indicating involvement in the earlier stages of the disease, a recent Singapore study has shown.
2 days ago
Resistance training appears to confer significant benefits for inflammation and insulin pathway profiles in postmenopausal breast cancer survivors, according to a study. However, the magnitude and degree of benefit from exercise may be influenced by whether or not women gained strength and/or lost weight during exercise.
Pearl Toh, 2 days ago
Patients with inflammatory bowel disease (IBD) who had primary nonresponse to an anti-tumour necrosis factor (TNF) agent ─ or inadequate response to the initial loading doses ─ were less likely to respond to second-line biologics compared with those who had secondary loss of response (LOR) or intolerance to the primary therapy, according to a systematic review and meta-analysis presented at the Crohn's & Colitis Congress (CCC) 2018 held recently in Las Vegas, Nevada, US.