Most Read Articles
23 Oct 2017
The use of e-cigarettes changes the innate defence protein profiles in airway secretions, a new study has shown. These changes may lead to questions about e-cigarettes as the supposed healthier alternative to smoking.
Rachel Soon, 04 Aug 2017

Investment in health crisis response systems during non-pandemic periods is crucial to combating the next inevitable flu pandemic, according to a government representative.

Audrey Abella, 14 Oct 2019
Use of the Zephyr endobronchial valve (EBV) led to significant improvements in a range of patient-reported outcomes (PROs) including multiple domains of respiratory symptoms and quality of life (QoL) in patients with severe emphysema, according to the post hoc results of the LIBERATE* trial presented at ERS 2019.
14 Oct 2019
Dr Helene Kobbernagel expounds on the role of azithromycin in primary ciliary dyskinesia in the BESTCILIA trial.

Low BMI, high PaCO2 predict 90-day mortality in severe COPD

27 Jul 2019

High partial pressure of carbon dioxide (PaCO2) and age, low body mass index (BMI), and previous admission for exacerbations of chronic obstructive pulmonary disease (ECOPD) in the last 2 years strongly predict 90-day mortality in patients with severe COPD, according to the Classification and Regression Tree (CART) analysis of a recent study.

“In absence of any of these factors, no patients died, suggesting that this model indeed enables risk stratification,” the authors said.

In total, 364 hospitalized patients (mean age, 70.5 years; 54.4 percent male; mean forced expiratory volume in 1 s [FEV1], 45.2 percent of predicted) were included in the analysis. The rate of in-hospital mortality was 8.5 percent and 90-day mortality 16.2 percent.

The following factors independently predicted 90-day mortality: PaCO2 (odds ratio [OR], 1.31, 95 percent CI, 1.00–0.35), age (OR, 1.09, 0.06–0.11), BMI <18.5 kg/m2 (OR, 2.72, 0.53–1.47) and previous admission for ECOPD in the last 2 years (OR, 1.29, –0.14 to –0.65). According to the CART model, the most discriminatory factors were PaCO2 ≥9.1 kPa, age >80 years, BMI <18.5 kg/m2 and previous admission for ECOPD.

“ECOPD [is] associated with increased in‐hospital and short‐term mortality,” the authors said. “Developing an easy‐to‐use model to predict adverse outcomes will be useful in daily clinical practice and will facilitate management decisions.”

This retrospective, observational, cohort study enrolled all patients with ECOPD admitted to Maastricht University Medical Center between June 2011 and December 2014. The authors considered the last admission and recorded its demographic, clinical and biochemical data.

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Most Read Articles
23 Oct 2017
The use of e-cigarettes changes the innate defence protein profiles in airway secretions, a new study has shown. These changes may lead to questions about e-cigarettes as the supposed healthier alternative to smoking.
Rachel Soon, 04 Aug 2017

Investment in health crisis response systems during non-pandemic periods is crucial to combating the next inevitable flu pandemic, according to a government representative.

Audrey Abella, 14 Oct 2019
Use of the Zephyr endobronchial valve (EBV) led to significant improvements in a range of patient-reported outcomes (PROs) including multiple domains of respiratory symptoms and quality of life (QoL) in patients with severe emphysema, according to the post hoc results of the LIBERATE* trial presented at ERS 2019.
14 Oct 2019
Dr Helene Kobbernagel expounds on the role of azithromycin in primary ciliary dyskinesia in the BESTCILIA trial.