Most Read Articles
Yesterday
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Jairia Dela Cruz, 2 days ago
Following vegan and vegetarian diets, which offer plenty of what is good for health, has been reported to have a downside: an increased risk of depression and anxiety, especially for younger adults.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
Christina Lau, 6 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Low BMI, high PaCO2 predict 90-day mortality in severe COPD

27 Jul 2019

High partial pressure of carbon dioxide (PaCO2) and age, low body mass index (BMI), and previous admission for exacerbations of chronic obstructive pulmonary disease (ECOPD) in the last 2 years strongly predict 90-day mortality in patients with severe COPD, according to the Classification and Regression Tree (CART) analysis of a recent study.

“In absence of any of these factors, no patients died, suggesting that this model indeed enables risk stratification,” the authors said.

In total, 364 hospitalized patients (mean age, 70.5 years; 54.4 percent male; mean forced expiratory volume in 1 s [FEV1], 45.2 percent of predicted) were included in the analysis. The rate of in-hospital mortality was 8.5 percent and 90-day mortality 16.2 percent.

The following factors independently predicted 90-day mortality: PaCO2 (odds ratio [OR], 1.31, 95 percent CI, 1.00–0.35), age (OR, 1.09, 0.06–0.11), BMI <18.5 kg/m2 (OR, 2.72, 0.53–1.47) and previous admission for ECOPD in the last 2 years (OR, 1.29, –0.14 to –0.65). According to the CART model, the most discriminatory factors were PaCO2 ≥9.1 kPa, age >80 years, BMI <18.5 kg/m2 and previous admission for ECOPD.

“ECOPD [is] associated with increased in‐hospital and short‐term mortality,” the authors said. “Developing an easy‐to‐use model to predict adverse outcomes will be useful in daily clinical practice and will facilitate management decisions.”

This retrospective, observational, cohort study enrolled all patients with ECOPD admitted to Maastricht University Medical Center between June 2011 and December 2014. The authors considered the last admission and recorded its demographic, clinical and biochemical data.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Respirology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Yesterday
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Jairia Dela Cruz, 2 days ago
Following vegan and vegetarian diets, which offer plenty of what is good for health, has been reported to have a downside: an increased risk of depression and anxiety, especially for younger adults.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
Christina Lau, 6 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.