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Roshini Claire Anthony, 2 days ago

Patients undergoing chemotherapy for breast or haematological cancers could potentially reduce their risk of chemotherapy-related cardiotoxicity with the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), or beta-blockers as primary prevention, according to a systematic review and meta-analysis presented at the recent EuroEcho 2019 conference.

Tristan Manalac, 3 days ago
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Lovastatin demonstrates anti-inflammatory effect in selected mild RA patients

18 Nov 2019

Treatment with lovastatin appears to have neither anti-inflammatory nor clinical effects on rheumatoid arthritis (RA) disease activity, although it produces a modest reduction in C-reactive protein (CRP) in patients not using biologics, according to the results of a phase II study.

The trial randomized 64 adult RA patients with mild disease activity but elevated CRP levels to receive either two 40-mg lovastatin tablets orally once daily or matching placebo for 12 weeks. Researchers measured the effect of treatment on mean log CRP as the primary endpoint.

Baseline characteristics were similar between the two treatment groups. Likewise, there was no significant between-group difference in the primary endpoint; lovastatin and placebo yielded similar reductions in mean log CRP.

Results for disease activity also did not significantly differ between the two treatment groups. Mechanistic analyses did not reveal substantial changes in titres of both rheumatoid factor and anticyclic citrullinated peptide antibodies.

In a posthoc analysis of patients not using biologic therapy, the group of those who were treated with lovastatin achieved a 20-percent decrease in CRP from baseline compared with the group treated with placebo (p-value=0.007). This difference was not observed among patients receiving biologics.

Lovastatin was well tolerated with no serious safety concerns.

The present data suggest that lovastatin may be anti-inflammatory in mild RA patients not treated with biologics, the researchers said.

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Most Read Articles
Roshini Claire Anthony, 2 days ago

Patients undergoing chemotherapy for breast or haematological cancers could potentially reduce their risk of chemotherapy-related cardiotoxicity with the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), or beta-blockers as primary prevention, according to a systematic review and meta-analysis presented at the recent EuroEcho 2019 conference.

Tristan Manalac, 3 days ago
Users of electronic nicotine delivery systems are likely to have received a diagnosis of clinical depression in the past, according to a recent study.
Pearl Toh, 06 Dec 2019
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.
6 days ago
While douching is not associated with the risk of ovarian cancer, the combination of talc and commercially available douches contributes to a modest increase in the risk of epithelial ovarian cancer beyond that conferred by talc use alone, as shown in a recent study.