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13 Jul 2019
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Longer spondyloarthritis disease duration ups risk of hypertension

06 Jul 2019

A higher risk of hypertension correlates with the disease duration of spondyloarthritis (SpA), particularly in axial disease, suggests a recent study. Moreover, exposure to nonsteroidal anti-inflammatory drugs (NSAID) does not seem to contribute to the risk of hypertension.

Analysis was performed using data from 3,923 patients (median SpA disease duration, 5.1 years; interquartile range, 1.3–11.8 years). The main cardiovascular (CV)-related conditions assessed were as follows: hypertension (22.4 percent), ischaemic heart disease (2.6 percent), stroke (1.3 percent) and diabetes mellitus (5.5 percent).

Both univariable and multivariable analyses showed an association between hypertension and SpA disease duration (odds ratio [OR] for each 5-year increase in disease duration, 1.129, 95 percent CI, 1.072–1.189; p<0.001). Apart from SpA disease duration, factors such as age, male sex, current body mass index, ever steroid therapy and ever synthetic disease-modifying antirheumatic drug therapy, but not NSAID, were also associated with hypertension.

In addition, subgroup analysis revealed that patients with the axial-only SpA phenotype were at greatest risk of hypertension (OR, 1.202, 1.053–1.372), but not those with peripheral-only SpA (OR, 0.902, 0.760–1.070). Other CV conditions did not show any association with SpA disease duration.

The investigators used data from the COMOSPA study to assess the associations between SpA disease duration and CV-related conditions in univariable and multivariable logistic regression models. Adjusting for relevant confounders, each model examined one CV-related factor as dependent and “SpA disease duration” as predictor.

“SpA is associated with a number of CV comorbidities,” the investigators noted.

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Most Read Articles
13 Jul 2019
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Pearl Toh, 6 days ago
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from the large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
13 Jul 2019
Treatment with metformin may improve whole-body and peripheral insulin resistance (IR) in youth who are overweight/obese with type 1 diabetes (T1D), according to a study.
6 days ago
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.