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Stephen Padilla, 6 days ago
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Longer spondyloarthritis disease duration ups risk of hypertension

06 Jul 2019

A higher risk of hypertension correlates with the disease duration of spondyloarthritis (SpA), particularly in axial disease, suggests a recent study. Moreover, exposure to nonsteroidal anti-inflammatory drugs (NSAID) does not seem to contribute to the risk of hypertension.

Analysis was performed using data from 3,923 patients (median SpA disease duration, 5.1 years; interquartile range, 1.3–11.8 years). The main cardiovascular (CV)-related conditions assessed were as follows: hypertension (22.4 percent), ischaemic heart disease (2.6 percent), stroke (1.3 percent) and diabetes mellitus (5.5 percent).

Both univariable and multivariable analyses showed an association between hypertension and SpA disease duration (odds ratio [OR] for each 5-year increase in disease duration, 1.129, 95 percent CI, 1.072–1.189; p<0.001). Apart from SpA disease duration, factors such as age, male sex, current body mass index, ever steroid therapy and ever synthetic disease-modifying antirheumatic drug therapy, but not NSAID, were also associated with hypertension.

In addition, subgroup analysis revealed that patients with the axial-only SpA phenotype were at greatest risk of hypertension (OR, 1.202, 1.053–1.372), but not those with peripheral-only SpA (OR, 0.902, 0.760–1.070). Other CV conditions did not show any association with SpA disease duration.

The investigators used data from the COMOSPA study to assess the associations between SpA disease duration and CV-related conditions in univariable and multivariable logistic regression models. Adjusting for relevant confounders, each model examined one CV-related factor as dependent and “SpA disease duration” as predictor.

“SpA is associated with a number of CV comorbidities,” the investigators noted.

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Most Read Articles
Stephen Padilla, 6 days ago
Early administration of recombinant human B-type natriuretic peptide (rhBNP) can lower the incidence of reperfusion injury for patients with ST-elevation myocardial infarction (STEMI) who are receiving percutaneous coronary intervention (PCI) treatment, according to a China study.
11 Aug 2019
Intraoperative methylprednisolone does not appear to significantly prevent the incidence of death, cardiac arrest and other injuries in neonates undergoing cardiac surgery with cardiopulmonary bypass, according to a recent study.
3 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.
Yesterday
Systolic blood pressure appears to have a strong association with aneurysmal subarachnoid haemorrhage (aSAH) but not with unruptured intracranial aneurysm (UIA), whereas current smoking and female sex are risk factors for both conditions, a study has found.