Longer sleep duration ups hypertension risk
People who sleep longer at night may be at a higher risk of diagnosed and undiagnosed hypertension, according to a recent study.
Researchers enrolled 37,317 participants (mean age 56.00±12.06 years; 22,843 females) who were classified according to the duration of sleep at night: <5, 5–6, 6–7, 7–8, 8–9, 9–10 and ≥10 hours. Logistic regression models were then used to determine the relationship between sleep duration and hypertension.
At baseline, 12,333 participants had hypertension. The age-standardized prevalence was higher for males than for females (21.24 percent vs 15.95 percent).
Analysis stratified according to sleep duration showed that in males, the age-adjusted prevalence of hypertension was higher in those with <5 vs ≥10 hours of sleep at night (33.77 percent vs 40.27 percent; p<0.001 for trend). The same was true for females (27.39 percent vs 32.48 percent; p<0.001).
Similar trends were observed for undiagnosed (males: 14.46 percent vs 25.13 percent; females: 9.20 percent vs 13.13 percent) and diagnosed (males: 24.70 percent vs 24.90 percent; females: 19.80 percent vs 22.55 percent; p<0.001 for trend for all) hypertension in those with <5 vs ≥10 hours of nightly sleep.
These findings were confirmed in regression models, which demonstrated that participants with longer sleep durations (≥10 hours) were significantly correlated with a higher risk of hypertension than those with 7–8 hours of sleep in males (odds ratio [OR], 1.52; 95 percent CI, 1.25–1.84). This effect was only approaching significance in females (OR, 1.11; 0.95–1.30).
Mediation analysis further found that levels of low-density lipoprotein cholesterol accounted for a significant 3.5 percent of the increased odds of hypertension in males with ≥10 hours of sleep at night (OR, 1.003; 1.001–1.137).