Most Read Articles
Pearl Toh, 20 Nov 2019
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Longer DAPT courses not more effective at preventing adverse outcomes

11 Jan 2020

Prolonged dual antiplatelet therapy (DAPT) in acute myocardial infarction (MI) patients treated with drug-eluting stents (DES) does not appear to be particularly advantageous to shorter treatment durations, a recent study has found.

Researchers enrolled 6,199 acute MI patients who were given 12 months of DAPT after percutaneous coronary intervention with DES. The primary study endpoint was the occurrence of major adverse cardiovascular and cerebrovascular events (MACCE), defined as a composite of MI, ischaemic stroke and all-cause death.

Participants were divided into two groups according to the duration of DAPT: 4,802 (mean age, 62.1±12.1 years; 78.3 percent male) received a prolonged regimen of >12 months, while 1,397 (mean age, 60.9±11.7 years; 79.9 percent male) took the medication for 12 months. Second-generation DES saw predominant use in either treatment group.

After inverse probability treatment-weighted adjustment, the incidence rate of MACCE was comparable between those who received the longer vs shorter DAPT course (1.3 percent vs 1.0 percent; hazard ratio [HR], 1.32, 95 percent confidence interval [CI], 0.71–2.45; p=0.378).

The same was true for the corresponding rates of the individual components of the composite outcome: death from any cause (0.1 percent vs 0.1 percent; HR, 1.02, 95 percent CI, 0.19–5.41; p=0.983), MI (0.8 percent vs 0.6 percent; p=0.650) and ischaemic stroke (0.4 percent vs 0.2 percent; p=0.229). The incidence of net adverse clinical events was likewise similar between groups (1.4 percent vs 1.1 percent; p=0.466).

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Most Read Articles
Pearl Toh, 20 Nov 2019
The trade-off between the risk of ischaemic vs bleeding events may be different between Asian and non-Asian patients, which warrants careful consideration when deciding on the duration of antiplatelet therapy following a percutaneous coronary intervention (PCI), according to a presentation at ESC Asia Congress 2019.
3 days ago
Participating in a long-distance skiing event may help lower the risk of hypertension, with the number of completed races showing a weak association with the risk, a study has found.
06 Sep 2019
Hypertensive adults with lower plasma zinc concentration are at increased risk of haemorrhagic stroke, especially those with higher body mass index or lower plasma copper levels, a study has found.
06 Jan 2020
Target organ damage appears to be more noticeable in patients affected by primary aldosteronism than those affected by arterial hypertension without primary aldosteronism, suggests a study, adding that specific treatment can ease such condition.