Most Read Articles
Stephen Padilla, 21 Jul 2017
Adherence to a beneficial lifestyle may significantly reduce the risk of chronic hypertension after hypertensive disorders of pregnancy (HDP) such as gestational hypertension and pre-eclampsia, a recent study suggests. Keeping a healthy weight appears to be critical in women with a history of HDP compared with those without such a history.
Natalia Reoutova, 4 days ago

MitraClip NTR and XTR systems are effective and well tolerated for primary mitral regurgitation (MR), as shown in the prospective, multicentre, single-arm, international, post-marketing, real-world, observational EXPAND study presented at the American College of Cardiology 2020/World Congress of Cardiology (ACC.20/WCC) virtual meeting.

Pearl Toh, Yesterday
Taking ticagrelor alone — and dropping aspirin — after 3 months of DAPT* post-PCI** significantly reduced bleeding events without increasing the risk of ischaemic adverse events compared with continuing a DAPT of ticagrelor plus aspirin, the TICO*** trial has shown.
09 Jul 2017
The Dietary Approaches to Stop Hypertension (DASH) diet is effective in reducing uric acid concentrations and risks of gout in males, a new prospective cohort study reveals. In contrast, Western diets up the risk of gout.

Longer DAPT courses not more effective at preventing adverse outcomes

11 Jan 2020

Prolonged dual antiplatelet therapy (DAPT) in acute myocardial infarction (MI) patients treated with drug-eluting stents (DES) does not appear to be particularly advantageous to shorter treatment durations, a recent study has found.

Researchers enrolled 6,199 acute MI patients who were given 12 months of DAPT after percutaneous coronary intervention with DES. The primary study endpoint was the occurrence of major adverse cardiovascular and cerebrovascular events (MACCE), defined as a composite of MI, ischaemic stroke and all-cause death.

Participants were divided into two groups according to the duration of DAPT: 4,802 (mean age, 62.1±12.1 years; 78.3 percent male) received a prolonged regimen of >12 months, while 1,397 (mean age, 60.9±11.7 years; 79.9 percent male) took the medication for 12 months. Second-generation DES saw predominant use in either treatment group.

After inverse probability treatment-weighted adjustment, the incidence rate of MACCE was comparable between those who received the longer vs shorter DAPT course (1.3 percent vs 1.0 percent; hazard ratio [HR], 1.32, 95 percent confidence interval [CI], 0.71–2.45; p=0.378).

The same was true for the corresponding rates of the individual components of the composite outcome: death from any cause (0.1 percent vs 0.1 percent; HR, 1.02, 95 percent CI, 0.19–5.41; p=0.983), MI (0.8 percent vs 0.6 percent; p=0.650) and ischaemic stroke (0.4 percent vs 0.2 percent; p=0.229). The incidence of net adverse clinical events was likewise similar between groups (1.4 percent vs 1.1 percent; p=0.466).

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Most Read Articles
Stephen Padilla, 21 Jul 2017
Adherence to a beneficial lifestyle may significantly reduce the risk of chronic hypertension after hypertensive disorders of pregnancy (HDP) such as gestational hypertension and pre-eclampsia, a recent study suggests. Keeping a healthy weight appears to be critical in women with a history of HDP compared with those without such a history.
Natalia Reoutova, 4 days ago

MitraClip NTR and XTR systems are effective and well tolerated for primary mitral regurgitation (MR), as shown in the prospective, multicentre, single-arm, international, post-marketing, real-world, observational EXPAND study presented at the American College of Cardiology 2020/World Congress of Cardiology (ACC.20/WCC) virtual meeting.

Pearl Toh, Yesterday
Taking ticagrelor alone — and dropping aspirin — after 3 months of DAPT* post-PCI** significantly reduced bleeding events without increasing the risk of ischaemic adverse events compared with continuing a DAPT of ticagrelor plus aspirin, the TICO*** trial has shown.
09 Jul 2017
The Dietary Approaches to Stop Hypertension (DASH) diet is effective in reducing uric acid concentrations and risks of gout in males, a new prospective cohort study reveals. In contrast, Western diets up the risk of gout.