Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
2 days ago
Among patients with moderate-to-severe psoriasis, the use of biologics appears to lower the risk of being hospitalized for the novel coronavirus disease (COVID-19), a new study has found.

Longer, poor sleep linked to higher arterial stiffness in hypertensive adults

15 Dec 2020

Longer and poorer-quality sleep may promote higher brachial-ankle pulse wave velocity (baPWV) among patients with hypertension, a recent study suggests.

A total of 14,485 hypertensive adults (mean age, 64.4±7.4 years; 40.2 percent male) participated in the cross-sectional analysis. BaPWV was measured using a noninvasive vascular function analyser, and a value of ≥1,800 cm/s was deemed to indicate arterial stiffness. Sleep quality and duration were assessed through questionnaires.

The average baPWV in the overall cohort was 1,727.4±340.3. Participants were then grouped into three according to sleep duration: <5, 5–8, and ≥8 hours. Those who slept longer tended to be older, male, smokers, and drinkers.

In addition, multivariate analysis showed that adults who slept for ≥8 hours had significantly greater baPWV (β, 13.7 cm/s, 95 percent confidence interval [CI], 3.9–23.5), as well as a nominally higher prevalence of arterial stiffness (odds ratio [OR], 1.08, 95 percent CI, 0.99–1.19), than their counterparts with <8 hours of sleep.

In terms of sleep quality, participants were also grouped into three (good, medium, poor). Those with poor sleep had greater baPWV (β, 16.3 cm/s, 95 percent CI, 0.1–32.6) and prevalence of arterial stiffness (OR, 1.13, 95 percent CI, 0.97–1.32), than adults with good/medium sleep.

Moreover, participants who slept for ≥8 hours and/or had poor sleep quality had significantly greater baPWV than comparators with <8-hour sleep duration and good/medium sleep quality (β, 14.4 cm/s, 95 percent CI, 5.3–23.4).

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
2 days ago
Among patients with moderate-to-severe psoriasis, the use of biologics appears to lower the risk of being hospitalized for the novel coronavirus disease (COVID-19), a new study has found.