Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Long working hours factor in masked, sustained hypertension

10 Jan 2020

Individuals working long hours are at greater odds of having masked or sustained hypertension, a study has found.

Researchers looked at 3,547 white-collar workers and collected data at three time points over 5 years. All participants completed a questionnaire to report their work hours, which were categorized as 21–34, 35–40, 41–48 and 49 hours per week.

The mean of the first three blood pressure (BP) readings taken at rest at the workplace was calculated and designated as the workplace clinic BP, whereas the mean of the next readings recorded every 15 minutes during daytime working hours defined the ambulatory BP (ABP).

The overall prevalence of masked and sustained hypertension was 13.5 percent and 18.7 percent, respectively. Masked hypertension was characterized as clinic BP <140/90 mm Hg and ABP ≥135/85 mm Hg, while sustained hypertension was defined as clinic BP ≥140/90 mm Hg and ABP ≥135/85 mm Hg or receipt of treatment.

Multivariable analysis using Poisson regression revealed that working ≥49 hours per week was associated with a higher prevalence of masked hypertension (prevalence ratio [PR], 1.70, 95 percent confidence interval [CI], 1.09–2.64) and sustained hypertension (PR, 1.66, 95 percent CI, 1.15–2.50).

In light of the findings, the researchers underscored the usefulness of assessing working hours for the early identification of at-risk workers who could benefit from ABP monitoring.

The present study should raise clinical awareness regarding the deleterious effect of working long hours, which can, in turn, contribute to hypertension prevention and management at both individual and population levels, they added.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.