Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
3 days ago
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.

Long-term use of double internal stents provides durable relief in EMUO

14 Apr 2020

Use of double internal stents (DIS) in the long term offers durable relief in patients with secondary extrinsic malignant ureteral obstruction (EMUO), reveals a study. DIS avoids the use of external tubes and improves quality of life, making it a valuable alternative to other methods of urinary diversion.

From 2007 to 2019, DIS of 75 renal units were performed in 62 patients (mean age, 60 years; 79 percent female) presenting with EMUO using dwelling 7 FR stents. The investigators conducted surveillance every 3 months. Stents were exchanged routinely every year. Need for permanent stents’ retrieval was deemed a failure.

Risk factors for stent failure and mortality were assessed using univariate and multivariate analyses. Kaplan-Meier estimations provided maintenance of stent patency and disease-specific survival (DSS).

Thirty patients (48 percent) required balloon dilation. The median follow-up was 35.2 months (interquartile range, 26.8–46.7), while the median DSS was 21 months (range, 7.1–45.5). Thirty-nine patients died during the study period, of whom 37 (95 percent) had patent stents in place.

In multivariate analysis, mortality was found to be independently predicted by estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2 (hazard ratio [HR], 2.1, 95 percent confidence interval [CI], 1.1–4.2; p=0.02) and balloon dilation (HR, 2.1, 95 percent CI, 1.1–4.1; p=0.02).

Stent failure occurred in six patients (10 percent) due to the following: sepsis, intractable haematuria or creatinine elevation. The mean time to failure was 15 months. Radiation (p=0.038) and eGFR <45 ml/min/1.73 m2 (p=0.001) at presentation independently correlated with stent failure. Forty percent of patients reported stent-related side effects, such as irritative symptoms and haematuria.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
3 days ago
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.