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Long-term sublingual immunotherapy ups peanut desensitization in allergic kids

13 Nov 2019
A wearable patch has been developed to treat children and young adults with peanut allergy

Extended sublingual immunotherapy (SLIT) with peanut allergen clinically improves desensitization in children allergic to the food, a recent study has found.

Researchers enrolled 48 children (median age, 6.5 years; 67 percent male) with peanut allergies and who were subjected to extended maintenance SLIT with 2 mg/d of peanut protein for up to 5 years. Desensitization was evaluated using a double-blind, placebo-controlled food challenge trial. SLIT discontinuation was allowed only in those with skin test wheals <5 mm and peanut-specific immunoglobulin E (IgE) levels <15 kU/L.

A total of 75,366 total doses were delivered over the entire study period, of which only 4.78 percent (n=3,599) led to symptoms of side effects, affecting 45 of the 48 included children. Almost all of the symptoms resolved on their own, such that only 0.21 percent (n=158) required antihistamines. None of the children required epinephrine.

Thirty-seven participants were able to complete the study protocol and qualified for the food challenge trial. Majority (n=32; 67 percent) were able to consume at least 750 mg of peanut protein, while almost half (n=23; 48 percent) could tolerate at least 1,750 mg. A quarter (n=12; 25 percent) passed the food challenge, successfully intaking 5,000 mg of peanut protein without showing clinical symptoms.

This improvement in desensitization was accompanied by a significant decrease in median wheal size from baseline to study end (11.8 to 7.8 mm; p=0.049). The same was true for levels of peanut-specific IgEs (83.9 to 20.0 kU/L; p<0.0001).

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Most Read Articles
Roshini Claire Anthony, 23 hours ago

Patients undergoing chemotherapy for breast or haematological cancers could potentially reduce their risk of chemotherapy-related cardiotoxicity with the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), or beta-blockers as primary prevention, according to a systematic review and meta-analysis presented at the recent EuroEcho 2019 conference.

6 days ago
Men who undergo flexible cystoscopy, particularly with a longer dwell time, may benefit from intraurethral lidocaine as it provides significant pain reduction, suggest the results of a meta-analysis. Evidence is lacking for other tested interventions.
Tristan Manalac, 2 days ago
Users of electronic nicotine delivery systems are likely to have received a diagnosis of clinical depression in the past, according to a recent study.
Pearl Toh, 5 days ago
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.