Most Read Articles
2 days ago
Chest pain appears to be the principal complaint of patients hospitalized with a first myocardial infarction (MI), particularly among those in the youngest age group, a study has found.
Jairia Dela Cruz, 16 Sep 2020
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 2 days ago
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
3 days ago
Women with pre-eclampsia are at higher risk of developing heart failure, a study suggests.

Long-term sublingual immunotherapy ups peanut desensitization in allergic kids

13 Nov 2019
A wearable patch has been developed to treat children and young adults with peanut allergy

Extended sublingual immunotherapy (SLIT) with peanut allergen clinically improves desensitization in children allergic to the food, a recent study has found.

Researchers enrolled 48 children (median age, 6.5 years; 67 percent male) with peanut allergies and who were subjected to extended maintenance SLIT with 2 mg/d of peanut protein for up to 5 years. Desensitization was evaluated using a double-blind, placebo-controlled food challenge trial. SLIT discontinuation was allowed only in those with skin test wheals <5 mm and peanut-specific immunoglobulin E (IgE) levels <15 kU/L.

A total of 75,366 total doses were delivered over the entire study period, of which only 4.78 percent (n=3,599) led to symptoms of side effects, affecting 45 of the 48 included children. Almost all of the symptoms resolved on their own, such that only 0.21 percent (n=158) required antihistamines. None of the children required epinephrine.

Thirty-seven participants were able to complete the study protocol and qualified for the food challenge trial. Majority (n=32; 67 percent) were able to consume at least 750 mg of peanut protein, while almost half (n=23; 48 percent) could tolerate at least 1,750 mg. A quarter (n=12; 25 percent) passed the food challenge, successfully intaking 5,000 mg of peanut protein without showing clinical symptoms.

This improvement in desensitization was accompanied by a significant decrease in median wheal size from baseline to study end (11.8 to 7.8 mm; p=0.049). The same was true for levels of peanut-specific IgEs (83.9 to 20.0 kU/L; p<0.0001).

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
2 days ago
Chest pain appears to be the principal complaint of patients hospitalized with a first myocardial infarction (MI), particularly among those in the youngest age group, a study has found.
Jairia Dela Cruz, 16 Sep 2020
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 2 days ago
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
3 days ago
Women with pre-eclampsia are at higher risk of developing heart failure, a study suggests.