Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Long-term sublingual immunotherapy ups peanut desensitization in allergic kids

13 Nov 2019
A wearable patch has been developed to treat children and young adults with peanut allergy

Extended sublingual immunotherapy (SLIT) with peanut allergen clinically improves desensitization in children allergic to the food, a recent study has found.

Researchers enrolled 48 children (median age, 6.5 years; 67 percent male) with peanut allergies and who were subjected to extended maintenance SLIT with 2 mg/d of peanut protein for up to 5 years. Desensitization was evaluated using a double-blind, placebo-controlled food challenge trial. SLIT discontinuation was allowed only in those with skin test wheals <5 mm and peanut-specific immunoglobulin E (IgE) levels <15 kU/L.

A total of 75,366 total doses were delivered over the entire study period, of which only 4.78 percent (n=3,599) led to symptoms of side effects, affecting 45 of the 48 included children. Almost all of the symptoms resolved on their own, such that only 0.21 percent (n=158) required antihistamines. None of the children required epinephrine.

Thirty-seven participants were able to complete the study protocol and qualified for the food challenge trial. Majority (n=32; 67 percent) were able to consume at least 750 mg of peanut protein, while almost half (n=23; 48 percent) could tolerate at least 1,750 mg. A quarter (n=12; 25 percent) passed the food challenge, successfully intaking 5,000 mg of peanut protein without showing clinical symptoms.

This improvement in desensitization was accompanied by a significant decrease in median wheal size from baseline to study end (11.8 to 7.8 mm; p=0.049). The same was true for levels of peanut-specific IgEs (83.9 to 20.0 kU/L; p<0.0001).

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.