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13 Apr 2018
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Long-term SSRI delays progression of mild cognitive impairment to Alzheimer’s disease

08 Mar 2018

Long-term treatment with selective serotonin reuptake inhibitors (SSRI) appear to delay the progression of mild cognitive impairment (MCI) to Alzheimer’s disease, a recent study has shown.

The study included 755 nondepressed individuals with amnestic MCI or early Alzheimer’s dementia and age-matched cognitively normal controls. Kaplan-Meier survival analysis was performed to evaluate the effect of depression history and antidepressant treatments on the conversion to dementia.

While baseline MCI was associated with a 2.60-fold higher likelihood of prior depression, subsequent conversion to Alzheimer’s dementia was not. The cumulative probabilities of progression to Alzheimer’s dementia were statistically comparable between those with and without a history of depression (p=0.38).

When restricting analysis to MCI patients with a history of depression, those who received long-term treatment with SSRIs (>4 years) had a significant delay in progression to Alzheimer’s dementia compared with those who were treated with other antidepressants (change in mean survival time, 891 days; p≤0.001) or who received only short-term SSRI treatment (change in mean survival time, 884 days; p=0.008).

Compared to those without a history of depression who did not receive antidepressants, those with prior depression who took other antidepressants had significantly higher conversion rates (change in mean survival time, –654 days; p=0.003).

“[W]e found a delay of approximately 3 years in MCI progression to Alzheimer’s dementia in patients with a previous depression who received long-term SSRI treatment. In contrast, treatment with non-SSRI antidepressants was associated with a higher risk of conversion of MCI to Alzheimer’s dementia and a shorter interval to progression compared with the long-term SSRI group,” researchers said.

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Most Read Articles
13 Apr 2018
There appears to be a subgroup of schizophrenic patients who exhibit autism spectrum disorder (ASD) features characterized by specific symptomatological and cognitive profile, a study has found.
11 Mar 2018
Patients with schizophrenia may benefit from cannabidiol treatment, which produces significant improvements in psychotic symptoms and modest positive effects on cognitive performance and overall functioning, according to a recent study.