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Pearl Toh, 2 days ago
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 4 days ago
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Pearl Toh, 21 Sep 2020
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Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.

Long-term ICD survival more evident in patients with ischaemic HF, NYHA functional class II

01 Aug 2020
The implantable cardioverter defibrillator (ICD) is a small device implanted under the skin in the chest, to help control life-threatening arrhythmias.

Heterogenous treatment-related patterns of long-term survival with implantable cardioverter defibrillator (ICD) therapy have been observed among patients who participated in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) over 11 years of follow-up, with the benefit most apparent for those with ischaemic heart failure (HF) and those with New York Heart Association (NYHA) functional class II symptoms at trial enrolment.

Between 2010 and 2011, the authors analysed mortality outcomes for the 1,855 patients alive at the end of SCD-HeFT and combined these data with the 666 deaths from the original study to compare long-term outcomes overall and for key prespecified subgroups.

Over a median (25th to 75th percentiles) follow-up of 11.0 years, overall survival benefit favoured the ICD group compared with the placebo group (hazard ratio [HR], 0.87, 95 percent confidence interval [CI], 0.76–0.98; p=0.028) in intention-to-treat analysis. The ICD benefit attenuated after 6 years (pinteraction=0.0015) when treatment benefit was analysed as a function of time from randomization.

In subgroup analysis, ICD benefit in the long term varied depending on the HF aetiology and NYHA functional class: ischaemic HF (HR, 0.81, 95 percent CI, 0.69–0.95; p=0.009); nonischaemic HF (HR, 0.97, 95 percent CI, 0.79–1.20; p=0.802); NYHA functional class II (HR, 0.76, 95 percent CI, 0.65–0.90; p=0.001); NYHA functional class III (HR, 1.06, 95 percent CI, 0.86–1.31; p=0.575).

The SCD-HeFT randomly assigned 2,521 patients with moderate HF to amiodarone, placebo drug, or ICD therapy, with follow-up ending on 31 October 2003. Over a median follow-up of 45.5 months, amiodarone showed no effect on survival as compared with placebo, but ICD led to a 23-percent reduction in all-cause mortality.

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Most Read Articles
Pearl Toh, 2 days ago
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 4 days ago
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.