Most Read Articles
Yesterday
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
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Long-term exposure to fine particulate matter promotes kidney failure in CKD patients

16 Jun 2020

For patients with chronic kidney disease (CKD), exposure to fine particulate matter (PM2.5) in the long term may lead to progression to kidney failure with replacement therapy (KFRT), as reported in a recent study.

Researchers followed 6,628 adult CKD patients aged 20–90 years from the Advanced CKD Program in Taiwan. They evaluated the incidences of KFRT (defined as initiation of maintenance haemodialysis, peritoneal dialysis, or kidney transplantation) and all-cause mortality in relation to 1-year PM2.5 exposure prior to enrolment into the study.

During the follow-up, 941 KFRT events and 1,653 deaths occurred. Multivariable proportional hazard regression analysis revealed an association between the risk of progression to KFRT and PM2.5 exposure, such that the risk increased by nearly 20 percent per 7.8 μg/m3 greater PM2.5 (hazard ratio [HR], 1.19, 95 percent confidence interval [CI], 1.08–1.31).

Notably, the association followed a dose-response pattern. The adjusted HR estimates for progression to KFRT associated with low, medium, and high PM2.5 levels were 1.16 (95 percent CI, 0.90–1.51), 1.19 (95 percent CI, 0.94–1.52), and 1.42 (95 percent CI, 1.12–1.80), respectively.

There was no significant association between PM2.5 exposure and all-cause mortality (adjusted HR, 1.01, 95 percent CI, 0.95–1.08).

The study was limited by misclassification of PM2.5 exposure assessment and the potential for residual confounding.

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Most Read Articles
Yesterday
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
30 Jun 2020
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 5 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.