Most Read Articles
22 Nov 2020
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

4 days ago
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.
Pearl Toh, 2 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.

Long-term eslicarbazepine acetate safe, effective in focal epilepsy

19 Oct 2020

Use of eslicarbazepine acetate (ESL) over the long term in the treatment of patients with focal epilepsy appears to be well tolerated and induces freedom from seizures, according to the results of an open-label study.

The current analysis included 206 adult focal epilepsy patients completing a phase III randomized, noninferiority trial, with 96 receiving once‐daily ESL and 88 receiving twice‐daily controlled‐release carbamazepine (CBZ‐CR). All of them received ESL (800–1,600 mg/day) for 2 years in the open-label extension.

Treatment retention did not significantly differ between groups, although there was a trend toward low probability of ESL withdrawal. At month 24, the probability of ESL withdrawal was 0.0638 (95 percent confidence interval [CI], 0.0292–0.1366) in the ESL/ESL group and 0.0472 (95 percent CI, 0.0180–0.1210) in the CBZ‐CR/ESL group.

Majority of patients in both groups were free of seizures: 90.6 percent in the ESL/ESL group and 80.7 percent in the CBZ‐CR/ESL group (p=0.0531). Responder rates did not dip below 80 percent throughout the study.

Incidence of serious treatment-emergent adverse events (TEAEs) was similar between groups (7.3 percent vs 5.7 percent). The same was true for the occurrence of TEAEs considered at least possibly related to treatment (17.7 percent vs 18.2 percent) and TEAEs leading to discontinuation (3.1 percent vs 4.5 percent). The spectrum of events was generally consistent with the known safety profile of ESL.

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Most Read Articles
22 Nov 2020
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

4 days ago
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.
Pearl Toh, 2 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.