Most Read Articles
Stephen Padilla, 25 Jul 2019
Nonvitamin K antagonist oral anticoagulants (NOACs) appear to confer more clinical benefits to elderly patients with atrial fibrillation (AF) than vitamin K antagonist anticoagulants (VKAs), suggests a study, adding that this is primarily driven by the lower rates of major bleeding.
Rachel Soon, 05 Dec 2018

At the recent Malaysian Community Pharmacy Business Forum (MyCPBF), a discussion forum was held on the subject of “Transcending Primary Healthcare Services: The Future of Specialized Pharmacy Services and Pharmacy Specialization”.

12 Dec 2016

Associate Professor Ng Lee Ching, Director of the Environmental Health Institute (EHI) at the National Environment Agency (NEA), Singapore, speaks about the role of primary care physicians and government agencies in preventing dengue epidemics.

22 Aug 2018
In patients with atrial fibrillation (AF) naïve to oral anticoagulants (OACs), standard-dose nonvitamin K antagonist OACs (NOACs) provides better survival benefits than warfarin, a recent meta-analysis has shown.

Long‐term biological therapy likely needed in perianal Crohn’s disease management

01 Nov 2019

Discontinuation of antitumour necrosis factor (anti-TNF) therapy for perianal Crohn’s disease is highly likely to lead to relapse, with some patients even requiring defunctioning surgery, according to a study conducted across Asia.

The study population comprised 78 perianal CD patients from Hong Kong, Shanghai, Taiwan, Malaysia, Thailand and Singapore. All patients were treated with anti-TNF therapy with subsequent discontinuation.

A total of 44 patients (56.4 percent) relapsed after a median follow-up of 89 months. Relapse was defined as increased fistula drainage or recurrence of previously healed fistula after discontinuing anti-TNF therapy.

Cumulative probabilities of perianal CD relapse were 50.8 percent at 12 months, 72.6 percent at 36 months and 78.0 percent at 60 months. In multivariable Cox regression models, younger age at diagnosis of CD was associated with a 4-percent increased likelihood of developing perianal CD relapse (adjusted hazard ratio [HR], 1.04, 95 percent confidence interval [CI], 1.01–1.09; p=0.04).

Retreatment with anti-TNF induced remission in 24 of 29 patients (82.8 percent) with perianal CD relapse. Twelve patients (27.3 percent) needed defunctioning surgery, while one (2.3 percent) required proctectomy. Thiopurine maintenance had no beneficial effect on the risk of relapse (HR, 1.10, 95 percent CI, 0.58–2.12; p=0.77).

Five of the 17 patients (35.3 percent) who achieved radiological remission developed relapse after stopping anti-TNF therapy after a median of 6 months.

The findings highlight the importance of radiological assessment of perianal CD before stopping anti-TNF therapy, and that long-term biological therapy is most likely needed, according to researchers.

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Most Read Articles
Stephen Padilla, 25 Jul 2019
Nonvitamin K antagonist oral anticoagulants (NOACs) appear to confer more clinical benefits to elderly patients with atrial fibrillation (AF) than vitamin K antagonist anticoagulants (VKAs), suggests a study, adding that this is primarily driven by the lower rates of major bleeding.
Rachel Soon, 05 Dec 2018

At the recent Malaysian Community Pharmacy Business Forum (MyCPBF), a discussion forum was held on the subject of “Transcending Primary Healthcare Services: The Future of Specialized Pharmacy Services and Pharmacy Specialization”.

12 Dec 2016

Associate Professor Ng Lee Ching, Director of the Environmental Health Institute (EHI) at the National Environment Agency (NEA), Singapore, speaks about the role of primary care physicians and government agencies in preventing dengue epidemics.

22 Aug 2018
In patients with atrial fibrillation (AF) naïve to oral anticoagulants (OACs), standard-dose nonvitamin K antagonist OACs (NOACs) provides better survival benefits than warfarin, a recent meta-analysis has shown.