Most Read Articles
22 Oct 2018
Transdermal androgen appears beneficial to ageing patients with sex hormone deficiency-associated dry eye, with a recent study showing that short-term treatment relieves both symptoms and signs of the condition, as well as improves quality of life (QOL). These benefits are achieved without increasing the incidence of serious side effects.

Long-term aspirin use not associated with risk of neovascular AMD

03 Feb 2019
Time course of aspirin poisoning

Long-term regular use of low-dose aspirin for 5 years does not increase the risk of neovascular age-related macular degeneration (AMD), according to a recent study, suggesting the safety of long-term use of low-dose aspirin as regards the development of neovascular AMD.

The incidence of neovascular AMD was lower among nonregular vs regular aspiring users (3.5 vs 7.2 per 10,000 person-years) in the unmatched whole cohort. However, there was no association between aspirin use and neovascular AMD in propensity score-adjusted analysis (adjusted hazard ratio [HR], 0.98; 95 percent CI, 0.73–1.30).

Propensity score-matched analyses also showed no association, with comparable incidences of neovascular AMD between nonregular and regular aspirin users (7.5 vs 7.1 per 10,000 person-years; crude HR, 0.94; 0.70–1.28). Additionally, no association was seen in a maximally adjusted model, including age, sex, income, residential area and history of 100 randomly selected types of generic drugs (adjusted HR, 0.95; 0.71–1.28).

Using a nationwide cohort from a variety of clinical and hospital in South Korea, a retrospective population-based study was conducted involving nonregular and regular aspirin users under national health insurance (aged ≥45 years) who were followed from 2010–2015.

The investigators estimated the incidence per 10,000 person-years for neovascular AMD. Long-term regular use of low-dose aspirin was defined as sustained intake of ≤100 mg aspirin with ≥1,044 days prescription between 2005 and 2009. Nonregular aspirin users included occasional users or nonusers.

Several analyses were performed, as follows: propensity score-adjusted analysis in a large, randomly selected, unmatched whole cohort (n=482,613), propensity score-matched analysis in a matched cohort (n=74,196), and maximally adjusted analysis in the unmatched whole cohort (n=482,613).

Editor's Recommendations
Most Read Articles
22 Oct 2018
Transdermal androgen appears beneficial to ageing patients with sex hormone deficiency-associated dry eye, with a recent study showing that short-term treatment relieves both symptoms and signs of the condition, as well as improves quality of life (QOL). These benefits are achieved without increasing the incidence of serious side effects.