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Local retinal dysfunction strikes in type 1 diabetes patients showing no signs of DR

06 Nov 2018

Electroretinogram-assessed localized retinal dysfunction in type 1 diabetes mellitus (DM1) patients appears to occur even in the absence of clinical signs of diabetic retinopathy (DR), and this incidence is associated with ageing, according to a study.

Multifocal electroretinograms (mfERG) were recorded in 35 eyes of 18 patients with no DR, in 38 eyes of 19 patients with mild signs of nonproliferative DR (NPDR) and in 31 eyes of 17 healthy controls.

Researchers measured response amplitude densities (RADs) of the N1-P1 components, as well as P1 implicit times (ITs), from isolated (R1: 0°–2.5°, R2: 2.5°–5°, R3: 5°–10°) and combined (R1 + R2, R2 + R3 and R1 + R2 + R3) annular rings and from four retinal sectors (nasal, temporal, superior and inferior) with increasing eccentricities up to 10° (S1, S2, S3, S1 + S2, S1 + S2 + S3).

There were significant differences in mfERG RADs, but not ITs, from all isolated and combined rings and sectors up to 10° of foveal eccentricity between the DM1 groups and controls. Results were comparable between NO DR and NPDR DM1 patients.

On Pearson’s test, the mfERG abnormalities of the central retinal areas showed a significant correlation with age in both DM1 groups, as well as with diabetes duration but only in the NPDR group.

The findings point to the potential of using mfERG in detecting localized retinal areas with functional impairment, researchers said. Clinicians should be aware that neuroretinal dysfunction is present much in advance with respect to the clinical onset of DR.

The study data may prove useful in assessing functional (in association to structural) indicators of DR progression and identifying different phenotypes of DR with different risks of developing vision-threatening complications with the aim of understanding diabetic pathologic mechanisms and pursuing personalized management, researchers added.

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Most Read Articles
09 Jan 2019
Despite comparable efficacies, triamcinolone injections appear to be slightly superior over 5-fluorouracil injections for inducing keloid remission, a recent trial has found.
Jairia Dela Cruz, 6 days ago
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
Tristan Manalac, 6 days ago
Less than 15 percent of Singaporean adolescents get the recommended 8–10 hours of sleep on a school night, reports a recent study, noting that such short sleep duration is linked to symptoms of depression, overweight or obesity, and poorer self-rated health.
04 Jan 2019
Obstructive sleep apnoea may increase the risk of male-pattern baldness in men with a family history of hair loss, and this association appears to be mediated by low serum transferrin saturation levels related to hypoxia, a study suggests.