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2 days ago
Dairy consumption during adolescence or early adulthood does not appear to be associated with the overall risk of breast cancer, although results vary by hormone receptor status of tumours, a study has shown. Specifically, dairy intake is linked to higher ER–/PR– and lower ER+/PR+ cancer risk.
Roshini Claire Anthony, 5 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

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Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
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Liver resection offers hope for prolonged survival in patients with at least 10 CLM

16 Sep 2017

Liver resection after effective chemotherapy may afford prolonged long-term survival in patients with ≥10 colorectal liver metastases (CLM) staged with preoperative magnetic resonance imaging (MRI), a study has found.

Researchers evaluated the outcome after liver surgery and identified prognostic factors of survival in a cohort of 12,406 patients who had underwent operation for CLM. Data were prospectively collected in the LiverMetSuvey registry.

Overall, the group of patients with ≥10 CLM (n=529) had a 5-year overall survival (OS) of 30 percent. A macroscopically complete (R0/R1) resection was achieved in 72.8 percent of patients, yielding 3- and 5-year OS rates of 61 and 39 percent, respectively, vs 29 and 5 percent for patients with R2 or no resection (p<0.0001).

In a multivariate Cox proportional hazards model, R0/R1 resection emerged as the strongest favourable factor of OS (hazard ratio [HR], 0.35; 95 percent CI, 0.26 to 0.48). Other independent favourable factors were maximal tumour size <40 mm (HR, 0.67; 0.49 to 0.92), age <60 years (HR, 0.66; 0.50 to 0.88), preoperative MRI (HR, 0.65; 0.47 to 0.89) and adjuvant chemotherapy (HR, 0.73; 0.55 to 0.98).

The model also showed that 5-year OS rates of 30 percent might be achieved provided that R0/R1 resection was associated with at least one additional favourable factor.

The long-term outcome of patients with ≥10 CLM is worse compared with those who exhibit fewer lesions, with surgery performed following effective chemotherapy remaining the only hope of prolonged survival, particularly in patients for whom complete resection can be performed, researchers said.

Based on the current data, “the number of CLM should not be considered as contraindication to surgery per se and should encourage oncologists and surgeons to extend the surgical indications beyond commonly admitted boundaries,” they added.

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Most Read Articles
2 days ago
Dairy consumption during adolescence or early adulthood does not appear to be associated with the overall risk of breast cancer, although results vary by hormone receptor status of tumours, a study has shown. Specifically, dairy intake is linked to higher ER–/PR– and lower ER+/PR+ cancer risk.
Roshini Claire Anthony, 5 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

3 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
4 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.