Most Read Articles
Roshini Claire Anthony, 4 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 19 May 2018
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
2 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
3 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

Liver fibrosis indices predict portal hypertension in cirrhotic patients

05 Sep 2017
Serum indices of liver fibrosis show moderate diagnostic accuracy for portal hypertension (PH) in cirrhotic patients, reveals a recent study.

In a study cohort of 238 liver cirrhosis patients (mean age 52.55±10.44 years), 78.99 percent (n=188) had clinically significant PH (CSPH) while 68.49 percent (n=163) had severe PH (SPH).

Multivariate analysis showed that aminotransferase (AST; odds ratio [OR], 1.033; 95 percent CI, 1.031 to 1.034; p=0.005), platelet (PLT) count (OR, 0.993; 0.990 to 0.995; p=0.002) and albumin (OR, 0.943; 0.940 to 0.947; p=0.026) were independently and significantly associated with hepatic venous pressure gradient (HVPG) grade.

The resulting HVPG prediction model yielded areas under the curve (AUCs) of 0.780 (0.722 to 0.831) and 0.769 (0.711 to 0.821) for the prediction of CSPH and SPH, respectively. The corresponding sensitivities were 68.62 and 69.33 percent, while the specificities were 80.0 and 74.67 percent, respectively.

Of the live fibrosis indices used, King’s score (AUC, 0.755), AST-to-PLT ratio index (APRI; AUC, 0.742) and Lok index (AUC, 0.740) had the best diagnostic performance for CSPH. APRI showed the highest accuracy (76.89 percent), while King’s score was significantly better than FIB-4 (p=0.0002) and Forns index (p=0.0002).

For SPH, receiver operating curve analysis showed that King’s score (AUC, 0.742), APRI (AUC, 0.722) and Lok index (AUC, 0.717) again had the best diagnostic performance. Lok index had the highest accuracy (68.91 percent).

Lok index and King’s score were then combined. The resulting diagnostic performance outcome for CSPH was a 52.7 percent sensitivity and 90.4 percent specificity. For SPH, the sensitivity of the model was 34.55 percent while its specificity was 94.7 percent.

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Most Read Articles
Roshini Claire Anthony, 4 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 19 May 2018
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
2 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
3 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.