Most Read Articles
Roshini Claire Anthony, 5 days ago

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

Jairia Dela Cruz, 11 Jan 2019
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
Elvira Manzano, 6 days ago
Treatment with two investigational, oral JAK inhibitors may be beneficial in individuals with moderate‐to‐severe alopecia areata (spot baldness), an autoimmune disease that can cause a lot of anxiety, according to an ongoing phase II study.
4 days ago
Discontinuing the use of tyrosine kinase inhibitors (TKIs) in the treatment of patients with chronic myeloid leukaemia appears to be feasible in real-life clinical practice in the context of close molecular monitoring, a study reports.

Liver disease, virologic response predict survival in cirrhotic HCC patients after RFA

10 Jan 2019

Virologic response and the severity of underlying liver disease predict long-term survival following radiofrequency ablation (RFA) in hepatocellular carcinoma (HCC) on cirrhosis, a recent study has shown.

Researchers enrolled 389 cirrhotic patients (median age 66 years; 76.6 percent male) who received RFA for HCC. Assessments were performed 1 month after RFA, every 3 months for the first 2 years and every 6 months for the following 2 years. Overall survival (OS), tumour recurrence and primary efficacy were among the study outcomes.

The primary efficacy rate of RFA was 86.1 percent; in 13.9 percent of the patients, more than one procedure was required to achieve complete ablation.

Median OS was determined to be 52.0 months; corresponding rates at 2, 5 and 10 years were 79.8 percent, 42.4 percent and 15.8 percent. Almost half of the deaths (49.5 percent) were related to HCC, while 24.0 percent of the deaths were due to liver disease, independent of HCC. The remaining 18.1 percent of deaths were due to nonliver-related causes.

Multivariate Cox proportional hazards regression models showed that age (hazard ratio [HR], 1.06; 95 percent CI, 1.04–1.08), a Child-Pugh score of B/C (HR, 2.75; 1.80–4.20) and gamma-glutamyl transferase levels >2N (HR, 1.53; 1.01–2.13) were all associated with an elevated risk of death. The same was true for alkaline phosphatase level >1.5N (HR, 2.68; 1.73–4.15).

In hepatitis C patients, OS was significantly longer in those who achieved a sustained virologic response relative to other patients (124.5 vs 49.2 months; p<0.001).  

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Most Read Articles
Roshini Claire Anthony, 5 days ago

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

Jairia Dela Cruz, 11 Jan 2019
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
Elvira Manzano, 6 days ago
Treatment with two investigational, oral JAK inhibitors may be beneficial in individuals with moderate‐to‐severe alopecia areata (spot baldness), an autoimmune disease that can cause a lot of anxiety, according to an ongoing phase II study.
4 days ago
Discontinuing the use of tyrosine kinase inhibitors (TKIs) in the treatment of patients with chronic myeloid leukaemia appears to be feasible in real-life clinical practice in the context of close molecular monitoring, a study reports.