Most Read Articles
30 Nov 2018
New drug applications approved by US FDA as of 16 - 30 November 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Roshini Claire Anthony, 4 days ago

A combination of tocilizumab and methotrexate reduced disease activity at 2 years compared with methotrexate plus prednisone in patients with early rheumatoid arthritis (RA), an effect not demonstrated with tocilizumab monotherapy.

Roshini Claire Anthony, 2 days ago

The use of intramuscular depot medroxyprogesterone acetate (DMPA-IM) did not increase a woman’s risk of acquiring HIV compared with the use of a copper intrauterine device (IUD) or a levonorgestrel implant, results of a study conducted by the ECHO* Trial Consortium show.

14 May 2019
At the recent GLYCEMIC GUARDIANS™ dinner symposium, three eminent speakers spoke on theindispensable role of medical nutrition therapy (MNT) in improving outcomes for patients with type2 diabetes (T2D).

Lithium treatment may prevent suicide-related events in patients with bipolar disorder

14 Aug 2017

The use of lithium treatment appears to be effective in patients with bipolar disorder with suspected suicidal intentions, according to a recent study. However, risk for suicide is only one of the many considerations when providing clinical care.

Researchers utilized within-individual designs in a register-based longitudinal cohort to examine the associations of lithium and valproate, the most common alternative to lithium, with the risk of suicide-related events and potential differences between the two drugs. They followed 51,535 individuals with bipolar disorder from 2005 to 2013 through linkage of several Swedish national registers.

Hazard ratios (HRs) of suicide-related events during treated vs untreated periods were estimated using stratified Cox regression. The population attributable fractions were also estimated to evaluate the public health impact for patients with bipolar disorder.

A total of 10,648 suicide-related events occurred during follow-up. Lithium treatment significantly reduced the incidence rate by 14 percent (HR, 0.86; 95 percent CI, 0.78 to 0.95), but valproate treatment did not (HR, 1.02; 0.89 to 1.15).

There was a statistically significant difference in HRs of suicide-related events between lithium and valproate. Based on estimates of the population attributable fraction, administering lithium during the entire follow-up could have prevented 12 percent (4 to 20 percent) of suicide-related events.

“Conclusions regarding lithium’s antisuicidal effect for bipolar disorder have been limited due to nonrepresentative subjects and potential confounding factors, including varying severity of illness,” according to researchers. “Findings regarding the effect of valproate … are inconsistent for suicidal behaviour.”

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Most Read Articles
30 Nov 2018
New drug applications approved by US FDA as of 16 - 30 November 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Roshini Claire Anthony, 4 days ago

A combination of tocilizumab and methotrexate reduced disease activity at 2 years compared with methotrexate plus prednisone in patients with early rheumatoid arthritis (RA), an effect not demonstrated with tocilizumab monotherapy.

Roshini Claire Anthony, 2 days ago

The use of intramuscular depot medroxyprogesterone acetate (DMPA-IM) did not increase a woman’s risk of acquiring HIV compared with the use of a copper intrauterine device (IUD) or a levonorgestrel implant, results of a study conducted by the ECHO* Trial Consortium show.

14 May 2019
At the recent GLYCEMIC GUARDIANS™ dinner symposium, three eminent speakers spoke on theindispensable role of medical nutrition therapy (MNT) in improving outcomes for patients with type2 diabetes (T2D).