Most Read Articles
Roshini Claire Anthony, 6 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

Stephen Padilla, 28 May 2020
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
3 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.

Liraglutide may have antiresorptive effect

05 Mar 2020

Use of liraglutide in patients with type 2 diabetes (T2D) does not appear to have any effect on bone resorption, even preserving bone mineral density (BMD) despite weight loss, as shown in a study.

Researchers randomized 60 patients with T2D to receive liraglutide 1.8 mg daily or placebo for 26 weeks. Half of the participants were women, and mean ages were 62 and 64 years in the liraglutide and the placebo groups, respectively. Mean body weight was 98.2 and 91.6 kg, respectively, while HbA1c was 50 mmol/mol in both groups. However, those in the liraglutide group had significantly higher trabecular bone volume per tissue volume (BV/TV; p=0.03) and trabecular thickness (Tb.Th; p=0.02) at the tibia.

The primary endpoint of p-collagen I cross-linked C-terminal telopeptide (p-CTX) increased by a mean of 0.07 μg/L on liraglutide (p<0.001) and by 0.03 μg/L on placebo (p=0.04), although the changes between them were not significantly different (p=0.16).

At week 4, patients in the liraglutide group showed significant reductions in weight (p<0.001) and and p-procollagen type 1 N-terminal propeptide (P1NP; p<0.01). P-P1NP levels increased between weeks 4 and 13 (p=0.03) and remained elevated thereafter. In comparison, weight and p-P1NP did not change in patients treated with placebo.

Hip BMD decreased from baseline to end of study in the placebo group, whereas no changes were observed in patients treated with liraglutide (p=0.01 difference between groups).

The present data suggest that liraglutide may have some antiresorptive effect, according to the researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 6 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

Stephen Padilla, 28 May 2020
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
3 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.