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Dr Michael Lim, a senior consultant at the Paediatric Pulmonary and Sleep Division, National University Hospital, Singapore, speaks to Roshini Claire Anthony on the rare disease that is cystic fibrosis.

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Lifestyle interventions effective against nonobese NAFLD patients

06 Dec 2018

Lifestyle interventions appear to effectively induce remission of nonalcoholic fatty liver disease (NAFLD) in both obese and nonobese patients, reports a new study.

The study included 154 NAFLD patients who were randomly assigned to receive usual care (n=77) or a 12-month lifestyle intervention programme and regular exercise (n=77). In each group, 39 and 38 patients had body mass index (BMI) <25 and 25 kg/m2, respectively. Proton-magnetic resonance spectroscopy was used to assess the primary outcome of NAFLD remission.

Significantly more patients with BMI <25 kg/m2 who received the intervention vs usual care had NAFLD remission at 12 months (67 percent vs 18 percent; p<0.001). In the respective groups, the mean decline in intrahepatic triglyceride content (IHTG) was 6.1 percent and 1.3 percent, the difference between which was statistically significant (p=0.001).

In patients with BMI 25 kg/m2, 61 percent of those who received the lifestyle intervention programme achieved NAFLD remission. This effect was significantly greater than that from usual care (21 percent; p<0.001). The resulting mean reductions in IHTG were 7.4 percent and 2.9 percent, respectively (p=0.004).

The effects of lifestyle intervention also appeared sustainable. A the 6-year follow-up, significantly more participants who received the exercise intervention vs controls had BMI lower than baseline (19.1 percent vs 8.6 percent; p=0.037).

Moreover, although rebound in body weight was observed after termination of the intervention, the mean change in body weight at year 6 was significantly more pronounced in the intervention vs control group (–1.9±4.7 vs 0.4±3.3 kg; p=0.0022).

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Most Read Articles
4 days ago

Dr Michael Lim, a senior consultant at the Paediatric Pulmonary and Sleep Division, National University Hospital, Singapore, speaks to Roshini Claire Anthony on the rare disease that is cystic fibrosis.

2 days ago
Susceptibility‐guided therapy is as effective as empiric modified bismuth quadruple therapy for the first-line treatment of Helicobacter pylori infection, with both yielding excellent eradication rates, as shown in a recent trial.
4 days ago
It appears that long-term consumption of fish and omega-3 fatty acid does not influence the risk of incident hypertension in middle-aged and older men, suggests a US study.
2 days ago
The risk factors and outcomes associated with an increased risk of permanent pacing include atrial fibrillation (AF) ablation, multivalve surgery and New York Heart Association (NYHA) functional class III/IV, a recent study has found.