Most Read Articles
Rachel Soon, 06 Feb 2017

Similarities in insulin signaling mechanisms between the brains of Alzheimer’s disease patients and the pancreas of diabetic patients may point the way to improved treatment for the former, according to researchers.

08 Sep 2019
High-resistant starch, low-protein flour improves blood glucose and lipid levels among people with early type 2 diabetic neuropathy, as well as improves their ability to prevent antioxidative stress, reports a recent study.

Lidocaine safe, effective for children with cluster seizures

21 Jul 2019

Lidocaine prolongs seizure remission without resulting in harmful side effects in children with cluster seizures, a recent study has found.

The study included four children (median age, 7 years; two boys) who received continuous intravenous infusion of 2% lidocaine for drug-resistant cluster seizures. Medication was first administered at a dose of 1 mg/kg/hour, which was then increased to 2–4 mg/kg/hour. Treatment continued for 5–10 days.

Complete seizure cessation was initially achieved after lidocaine infusion, though recurrence was observed after a few months. As a result, all patients had to take at least two antiepileptic drugs. Remission persisted for a mean of 2.4 months.

Notably, seizure frequency was reduced by 80–100 percent, which was sustained over the mean follow-up duration of 7.5 months. Moreover, no additional cases of cluster seizures occurred. All participants tolerated lidocaine medication well and did not experience treatment-related adverse events.

According to the authors, the present findings, together with the fact that seizure remission and reduction persisted even after lidocaine withdrawal, suggest that the drug may have a long-term antiepileptic effect. However, the risk of adverse events remains present, and medication should be immediately discontinued as soon as arrhythmia or other such side effects arise.

“Clinicians should be aware of possible adverse effects and necessity of sustained cardiological surveillance during the treatment,” they said, emphasizing the requirement for further studies to confirm the long-term efficacy and safety of lidocaine in these patients.                              

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Most Read Articles
Rachel Soon, 06 Feb 2017

Similarities in insulin signaling mechanisms between the brains of Alzheimer’s disease patients and the pancreas of diabetic patients may point the way to improved treatment for the former, according to researchers.

08 Sep 2019
High-resistant starch, low-protein flour improves blood glucose and lipid levels among people with early type 2 diabetic neuropathy, as well as improves their ability to prevent antioxidative stress, reports a recent study.