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Roshini Claire Anthony, 6 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

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Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.
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Short sleep duration is associated with an increased risk of myocardial infarction (MI), according to prospective observational and Mendelian randomization (MR) analyses.
Tristan Manalac, 6 days ago
The addition of ezetimibe improves statin treatment in acute coronary syndrome (ACS) patients with dyslipidaemia and low eicosapentaenoic acid-to-arachidonic acid (EPA/AA) ratio, resulting in a lowered risk of cardiovascular events compared to monotherapy, according to a study presented at the recently concluded 2019 Congress of the European Society of Cardiology (ESC 2019) held in Paris, France.

Lidocaine safe, effective for children with cluster seizures

21 Jul 2019

Lidocaine prolongs seizure remission without resulting in harmful side effects in children with cluster seizures, a recent study has found.

The study included four children (median age, 7 years; two boys) who received continuous intravenous infusion of 2% lidocaine for drug-resistant cluster seizures. Medication was first administered at a dose of 1 mg/kg/hour, which was then increased to 2–4 mg/kg/hour. Treatment continued for 5–10 days.

Complete seizure cessation was initially achieved after lidocaine infusion, though recurrence was observed after a few months. As a result, all patients had to take at least two antiepileptic drugs. Remission persisted for a mean of 2.4 months.

Notably, seizure frequency was reduced by 80–100 percent, which was sustained over the mean follow-up duration of 7.5 months. Moreover, no additional cases of cluster seizures occurred. All participants tolerated lidocaine medication well and did not experience treatment-related adverse events.

According to the authors, the present findings, together with the fact that seizure remission and reduction persisted even after lidocaine withdrawal, suggest that the drug may have a long-term antiepileptic effect. However, the risk of adverse events remains present, and medication should be immediately discontinued as soon as arrhythmia or other such side effects arise.

“Clinicians should be aware of possible adverse effects and necessity of sustained cardiological surveillance during the treatment,” they said, emphasizing the requirement for further studies to confirm the long-term efficacy and safety of lidocaine in these patients.                              

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

6 days ago
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.
6 days ago
Short sleep duration is associated with an increased risk of myocardial infarction (MI), according to prospective observational and Mendelian randomization (MR) analyses.
Tristan Manalac, 6 days ago
The addition of ezetimibe improves statin treatment in acute coronary syndrome (ACS) patients with dyslipidaemia and low eicosapentaenoic acid-to-arachidonic acid (EPA/AA) ratio, resulting in a lowered risk of cardiovascular events compared to monotherapy, according to a study presented at the recently concluded 2019 Congress of the European Society of Cardiology (ESC 2019) held in Paris, France.